MatthiasKretzler Ann ArborUnited States

Dr. Kretzler is the Warner-Lambert/Parke-Davis Professor of Internal Medicine/Nephrology and Computational Medicine and Bioinformatics. The overarching goal of his research is to bring targeted tretments to people with kidney diseases. To reach this goal he has developed a translational research pipeline centered on integrated systems biology analysis of renal disease. He leads together with Dr. Himmelfarb the NIDDK Kidney Precision Medicine (KPMP) Central Hub and Kidney Mapping Atlas Project (KMAP), the Nephrotic Syndrome Research Network (NEPTUNE), is a Principle Investigator (PI) of the Breakthrough T1D Cardio-Renal Center of Excellence at the University of Michigan, the PI of the Renal Precompetitive Consortium (RPC2). He has 30 years of experience in integration of bioinformatics, molecular and clinical approaches in 500 publications. He has a track record on interdisciplinary data integration of large-scale data sets in international multi-disciplinary research networks in the US, Europe, SE Asia and sub-Saharan Africa. These studies enable precision medicine across the genotype-phenotype continuum using carefully monitored environmental exposures, genetic predispositions, epigenetic markers, transcriptional networks, proteomic profiles, metabolic fingerprints, digital histological biopsy archive and prospective clinical disease characterization. The molecular mechanism identified have result in new disease predictors and successful trials of novel therapeutic modalities in kidney diseases. Matthias Kretzler was born in Bruchsal, Germany close to Heidelberg (and France). He received his medical training at the University of Heidelberg, Germany; Newcastle upon the Tyne in the U.K.; and at the University of Michigan and LMU Munich. For further details see miktmc.org