Exploring Complement System Dynamics: C3G and IgAN

Session description:
Recent data has demonstrated the critical role that the complement system plays in glomerular diseases. While in C3 glomerulopathy, the alternative pathway is mainly involved in its pathogenesis, in IgA nephropathy both the alternative and the lectin pathways have been reported as key drivers of this disease. As a result, the activation of these pathways of the complement system leads to the inflammatory process that characterizes these entities.
Learning objectives:
To understand the role the alternative and lectin pathways play in C3GN and IgAN. To identify the main differences in complement activation between both entities. To understand the rationale of approaching the complement system in ongoing clinical trials in C3GN and IgAN.