ImariMimura TokyoJapan

After graduating from the Faculty of Medicine, University of Tokyo in 2003 and completing residency training, I entered the doctoral program at the Graduate School of Medicine, University of Tokyo in 2007. I conducted research on the mechanisms of chronic kidney disease progression under hypoxic conditions. After completing my doctoral program in 2011, I comprehensively analyzed epigenetic changes induced by hypoxic stimulation and identified new factors related to histone modifications and non-coding RNAs. I proposed the concept of hypoxic memory, in the pathogenesis of AKI-to-CKD transition, in which AKI is stored intracellularly as hypoxic memory and contributes to the progression of CKD. Currently, as a specially appointed lecturer in the Division of Nephrology and Endocrinology, University of Tokyo Hospital, I am incorporating AI-based machine learning into basic research to identify important enhancers that contribute to the pathogenesis and to develop nucleic acid drugs targeting them.