PRE-DIALYSIS ARTERIOVENOUS FISTULA CREATION IMPROVES HAEMODIALYSIS OUTCOMES AND REDUCES INTERVENTION REQUIREMENTS: A SINGLE-CENTRE RETROSPECTIVE COHORT STUDY

 

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PRE-DIALYSIS ARTERIOVENOUS FISTULA CREATION IMPROVES HAEMODIALYSIS OUTCOMES AND REDUCES INTERVENTION REQUIREMENTS: A SINGLE-CENTRE RETROSPECTIVE COHORT STUDY

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JYOTI
BAHARANI
JYOTI BAHARANI jyoti.baharani@uhb.nhs.uk HEARTLANDS HOSPITAL (UHB) NEPHROLOGY BIRMINGHAM United Kingdom *
TAMASIN STEVENSON tamasin.stevenson@uhb.nhs.uk HEARTLANDS HOSPITAL (UHB) NEPHROLOGY BIRMINGHAM United Kingdom -
RABIAH AHMED rabiah.ahmed@uhb.nhs.uk HEARTLANDS HOSPITAL (UHB) NEPHROLOGY BIRMINGHAM United Kingdom -
 
 
 
 
 
 
 
 
 
 
 
 

Arteriovenous fistulas (AVFs) remain the preferred vascular access for patients with end-stage renal disease (ESRD) requiring haemodialysis (HD), offering superior long-term patency and reduced complication rates compared to arteriovenous grafts or central venous catheters (CVCs). Primary patency, defined as the time from AVF creation to first intervention or failure, is critical for successful renal replacement therapy. Early nephrology referral and timely AVF formation prior to dialysis initiation are recommended, yet real-world comparisons of pre- versus post-HD AVF creation are limited.

We conducted a retrospective cohort study of 949 patients undergoing AVF creation between January 2014 and September 2024. Patients were stratified into pre-dialysis (n=525) and established HD (n=424) groups. Primary outcomes included successful cannulation, time to first use, and need for pre-cannulation intervention. Secondary outcomes assessed intervention types, effectiveness, and factors associated with AVF failure. Comparative analyses were performed using appropriate statistical tests.

Successful cannulation was significantly higher in the pre-dialysis group (87.8%, 461/525) versus established HD patients (77.1%, 327/424) (p<0.001). Fewer pre-dialysis patients required pre-cannulation interventions (4.6%, 24/525) compared to HD patients (8.9%, 38/424) (p=0.006).
In the pre-dialysis group, fistuloplasty had 87.5% success (14/16); other procedures included branch ligation (n=1), AVF ligation for steal syndrome (n=1), and surgical thrombectomy (n=3).
In the HD group, fistuloplasty was effective in 64% (16/25); additional interventions included branch ligation (n=5) and thrombectomy (n=2).
Across both groups: 18 patients died before AVF use; 3 recovered renal function; 2 were transplanted; 9 transferred care; and 4 switched to peritoneal dialysis.

Pre-dialysis AVF formation was associated with significantly higher rates of successful use (87.8% vs 77.1%) and fewer interventions (4.6% vs 8.9%). These findings support guideline recommendations for early vascular access planning and underscore the importance of timely nephrology referral. Proactive AVF creation improves HD initiation outcomes, reduces CVC reliance, and optimises long-term vascular access durability in ESRD care.

 

Kewords