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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Kidney transplantation remains the optimal treatment for End-Stage Renal Disease, significantly improving patient survival and quality of life. However, long-term allograft survival is a major challenge, with half-lives typically falling bellow two decades. This challenge is often attributed to chronic injury, the cumulative effects of calcineurin inhibitor toxicity and immunologic insult over time. Due to the scarcity of these extreme long-term survivors, data on functional allograft survival exceeding 40 years are virtually non-existent in medical literature. This retrospective case series, from a single kidney transplantation center, describes five male patients who have successfully maintained functional kidney allografts for a minimum of four decades.
This is a retrospective case series of five male kidney transplant recipients, all with a functioning allograft for 40 years or more (Range: 40 to 45 years). The cohort was evaluated for current graft function (serum creatinine and Cr clearance), current and historic comorbidities, and long-term complications, specifically focusing on documented rejection episodes. The historical immunosuppression regimen was also analyzed.
The mean allograft survival was 41.6 +/- 2.07 years. The mean age of the recipients at the time of de transplant was 28 years (19,5-33). All patients were caucasian and received a living donor kidney transplantation, mean age of the donors 30 years (22-47,5). Current graft function remains remarkably stable: mean calculated Cr clearance was 76.9 mL/min (47.35-89.75). None of the five patients had any documented episode of acute or chronic rejection throughout the follow-up period. All patients have maintained a simplified maintenance immunosuppression regimen consisting of prednisone and azathioprine. Post-transplant complications included a high rate of Hypertension (80%) and a low rate of Diabetes Mellitus (20%). One patient (20%) developed post-transplant neoplasia (multiple skin and a tongue cancer).
This case series represents, to our knowledge, one of the longest documented series of functional kidney allograft survival worldwide. The key factor associated with this unprecedented longevity appears to be the complete absence of documented rejection episodes in all patients. This series highlights that, in a carefully selected patient cohort with high adherence and low immunological risk, the historical combination of Azathioprine and Prednisone can achieve extraordinary long-term outcomes, despite the recipient's advanced age and the absence of modern maintenance drugs.
