CLINICAL CHARACTERISTICS AND OUTCOMES OF CKRT AMONG PRAKI IN A TERTIARY CARE TEACHING HOSPITAL IN INDIA

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CLINICAL CHARACTERISTICS AND OUTCOMES OF CKRT AMONG PRAKI IN A TERTIARY CARE TEACHING HOSPITAL IN INDIA

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Co-author 1

K.Sree Harsha vardhan kshvardhan@gmail.com gandhi hospital Nehrology hyderabad India *

Co-author 2

Manjusha Yadla manjuyadla@gmail.com gandhi hospital Nehrology hyderabad India -

Co-author 3

Sreekanth B sreedoc2000@gmail.com gandhi hospital Nehrology hyderabad India -

Co-author 4

Srinivas P swathivasu194@gmail.com gandhi hospital Nehrology hyderabad India -

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Introduction

Pregnancy-related acute kidney injury (PrAKI) represents a major global public health issue, significantly impacting maternal and fetal outcomes. In developing countries, the primary causes of postpartum AKI are sepsis and postpartum hemorrhage.Continuous kidney Replacement Therapy (CKRT) is the therapy of choice for hemodynamically unstable patients and is the mainstay of multiorgan support in critically ill patients.

Methods

This was a single center, observation study conducted from June 2022 to July 2025 at Gandhi Hospital, Hyderabad, a tertiary care, public sector teaching hospital. 47 patients with PrAKI treated with CKRT as the initial mode of RRT were included in the study. Laboratory parameters at the time of admission, before CKRT and after CKRT were recorded. The primary outcome of the study was to measure maternal outcomes. Secondary outcomes were to assess CKRT characteristics. Complete recovery was defined as return of the serum creatinine to baseline or normal range at the time of discharge. Partial recovery was defined as the decrease in serum creatinine, not to baseline but independent of RRT requirements.

Results

163 (100%)PrAKI patients were admitted during the study period. 53(32.5%) patients were managed conservatively. 110(67.5%) patients underwent RRT of which 51 (46.4%) patients were initiated on CKRT. Out of 51 patients, 49 patients underwent CKRT in post partum period. 2 patients underwent CKRT during intrapartum period.

Conclusion

· 1.Out of 110 patients who underwent RRT, 51 patients (46.4%) underwent CKRT.

· 2.In 51 patients, 31(60.7%) patients are survivors

· 3.Higher WBC count, higher qSOFA scores, lower mean urea and creatinine clearance per session are associated with high mortality.

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