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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Residual kidney function (RKF) is a key component for peritoneal dialysis (PD) adequacy. More than having an essential role in clearance of small solutes, middle molecules and larger uremic toxins, RKF is also pivotal in regulation of fluid status. RKF is known to decline continuously with PD, but the RKF decline rate has been reported to diminish after PD initiation compared to before start of dialysis. However, to our knowledge, the RKF changes and associated factors at PD initiation have not yet been thoroughly studied.
In this study, we examined RKF just before and after PD initiation in 95 patients starting PD at Karolinska University Hospital, Stockholm from 2000 to 2019. All patients were included in another ongoing clinical study in patients starting dialysis, with prospectively collected data. Inclusion criteria for this study were ≥ 1 24-h urine collection before and ≥ 1 24-h urine collection after PD start. Urine collections up to 2 months from PD start were included in analyses. We defined PD start as start of continuous PD at home after finished in-center training or start of continuous PD in a hospital ward. RKF was calculated as the average of urea and creatinine clearance from 24-h urine collections (mGFR). Baseline data were recorded before PD start. We used Spearman’s correlation coefficient to investigate correlations between the change in mGFR from before to after PD start with associated factors.
mGFR and diuresis decreased markedly after PD start. Blood pressure followed the same pattern, but weight remained rather unchanged. There were negative correlations between mGFR decline and blood pressure and albuminuria before PD start, and a positive correlation with plasma carbon dioxide. No correlation was seen between mGFR decline and UF, but there was a negative correlation between diuresis decline and UF.
In conclusion, the results indicate that higher blood pressure, albuminuria and acidosis predispose to a faster RKF decline at PD start. UF correlated to decreased diuresis but not to change in mGFR. Hypothetically, this could indicate UF causing dehydration, also supported by a decreasing blood pressure, and autoregulation compensation by the kidneys with less diuresis. The results of this study could possibly help to identify patients with high risk of fast RKF decline at PD start. However, further study needs to confirm those findings.
