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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Uremic solutes, traditionally subdivided into small water-soluble compounds, protein-bound toxins, and larger middle molecules according to their removal patterns by dialysis, accumulate in the body as kidney function decreases. Uremic solutes can be removed by peritoneal dialysis (PD) to some extent, but different uremic solutes have varying degrees of clearance due to their different chemical properties. Also, pathological and physiological changes in the kidney and peritoneum with the increase of dialysis vintage affect the clearances of uremic solutes. We observed the long-term trends of renal, peritoneal and total clearances of different uremic solutes in a PD cohort and explored the potential influence factors on uremic solutes clearances.
The 5-year time profiles of renal, peritoneal, and total clearances of creatinine, urea nitrogen (UN), uric acid (UA), trimethylamine N-oxide (TMAO), phosphate, beta-2-microglobulin(β2-MG), interleukin-6 (IL-6), indoxyl sulfate (IS), and p-cresol sulfate (PCS) were investigated in 64 PD patients. The patients were divided into an early start and a late start group according to baseline estimated glomerular filtration rate to investigate the effect of dialysis initiation timing on uremic solutes clearances. Patients were also divided into incremental peritoneal dialysis (IPD) and full-dose PD groups to investigate the impact of PD strategy on uremic solutes clearances.
1.Peritoneal clearances of creatinine, UN, UA, and phosphate increased over time, while the peritoneal clearance of IL-6 showed a downward trend. The peritoneal clearances of TMAO, β2-MG, IS, and PCS did not change significantly. Notably, there was a rapid decline in the renal clearance of water-soluble solutes and protein-bound toxins in the first year after PD initiation.
2.Patients in early start group showed a lower level of variation and a higher average of renal clearances. But there were no significant differences in the average and variation levels of peritoneal clearances between the two groups.
3.Additionally, the average levels of total clearances of creatinine, UN, TMAO, phosphate and IS were higher in the early start group, while the average total clearance of PCS was lower.
4.IPD patients had a higher level of total clearances of uremic solutes than full-dose PD patients in the first three years after PD initiation. The disparity between the two groups gradually diminished when the dialysis vintage reached 4–5 years.
In a long-term follow-up period, the peritoneal clearance of water-soluble small toxins increased over time, but that of protein-bound toxins and middle molecules did not. Initiating PD when residual kidney function remains at a relatively high level and performing IPD may better improve the efficiency of PD and help preserve the renal clearance of uremic solutes.
