COMPARISONS OF CLINICAL OUTCOMES BETWEEN KIDNEY TRANSPLANT RECIPIENTS AND CKD PATIENTS IN ELDERLY PATIENTS: A PROPENSITY SCORE MATCHED ANALYSIS

 

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https://storage.unitedwebnetwork.com/files/1099/7d19b79f7c7942e94d5d9887081adc7d.pdf
COMPARISONS OF CLINICAL OUTCOMES BETWEEN KIDNEY TRANSPLANT RECIPIENTS AND CKD PATIENTS IN ELDERLY PATIENTS: A PROPENSITY SCORE MATCHED ANALYSIS

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Jin Sug
Kim
Jin Sug Kim jinsuk0902@naver.com Kyung Hee University Department of Nephrology Seoul Korea (Republic of) *
Jeong-Yeun Lee 25525@khmc.or.kr Kyung Hee University Department of Nephrology Seoul Korea (Republic of) -
Soo-Young Yoon lynnyoon41@gmail.com Kyung Hee University Department of Nephrology Seoul Korea (Republic of) -
Kyung Hwan Jeong aprilhwan@naver.com Kyung Hee University Department of Nephrology Seoul Korea (Republic of) -
Hyeon Seok Hwang hwanghsne@gmail.com Kyung Hee University Department of Nephrology Seoul Korea (Republic of) -
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Although kidney transplantation is considered the optimal treatment for end-stage kidney disease (ESKD), its risks and benefits in the elderly remain unclear. This study compared clinical outcomes between kidney transplant recipients and propensity score–matched individuals aged ≥65 years.

Elderly kidney transplant recipients and matched population were obtained from the Korean Organ Transplant Registry (KOTRY) and a National Health Insurance Service-Elderly Cohort Database (NHIS-ECD), respectively. A 1:1 exact propensity score-matching was performed to account for differences in age, sex, and estimated glomerular filtration rate. The primary outcomes were all-cause mortality, hospitalization for infection, progression to ESKD, and cardiovascular disease.

After 1:1 matching, 543 patients were included in each group. Elderly kidney transplant recipients had similar risks of all-cause mortality (adjusted hazard ratio [HR], 0.66; 95% confidence interval [CI], 0.41–1.07) and cardiovascular disease (adjusted HR, 0.78; 95% CI, 0.27–2.23) compared with matched elderly. However, the risk of progression to ESKD was significantly higher in the transplant group (adjusted HR, 3.51; 95% CI, 1.07–11.5), and they also experienced more frequent infection-related hospitalizations (adjusted HR, 3.91; 95% CI, 2.66–5.74).

Among individuals aged ≥65 years, kidney transplantation was not associated with increased risks of all-cause mortality or cardiovascular disease compared with matched elderly, while conferring higher risks of kidney failure and infection-related hospitalization.

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