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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Hyponatremia is a common electrolyte disorder frequently observed in hospitalized patients. Although cirrhosis is one of the major causes of hyponatremia and has been extensively studied, little is known about the direct relationship between alcohol consumption and hyponatremia. Therefore, this study aimed to investigate the association and prognosis of hyponatremia in patients with alcoholic and non-alcoholic liver diseases admitted for hepatology.
A retrospective study was conducted on patients admitted to the Department of Hepatology at Gyeongsang National University Hospital between March 2016 and August 2025. Patients aged 18 years or older whose primary cause of hospitalization was liver disease were included, while those with alcoholic or non-alcoholic cirrhosis were excluded. The enrolled patients were categorized into two groups: the alcoholic liver disease group (alcohol group) and the non-alcoholic liver disease group (non-alcohol group). The prevalence, prognosis, and mortality related to hyponatremia were compared between the two groups.
Among 2,032 hospitalized patients, 587 (28.9%) were alcohol Group and 1,445 (71.1%) were non-alcoholic controls. The mean age did not differ between groups (59.3 ± 10.1 vs. 60.5 ± 9.8 years, p = 0.12), but males (82.1% vs. 62.4%, p < 0.001) and chronic liver disease (46.3% vs. 20.7%, p < 0.001) were more common among alcohol group.
Hyponatremia (serum sodium <135 mmol/L) occurred in 584 patients (28.7%), with a significantly higher prevalence in alcohol group (43.6%) than in non-alcoholic patients (22.7%) (p < 0.001). Multivariate logistic regression identified heavy alcohol use as an independent risk factor for hyponatremia (adjusted OR = 2.63, 95% CI 2.14–3.24, p < 0.001), along with chronic liver disease (OR = 1.81, p = 0.004) and reduced renal function (OR = 1.58, p = 0.021). Hyponatremic patients had higher 30-day mortality (15.4% vs. 5.8%, p < 0.001), longer hospital stay (11.6 ± 6.9 vs. 9.1 ± 5.4 days, p = 0.007), and greater ICU admission (24.7% vs. 12.8%, p = 0.011). Cox regression confirmed hyponatremia as an independent predictor of all-cause mortality (adjusted HR = 1.94, 95% CI 1.32–2.84, p = 0.001). In the heavy alcohol subgroup, concomitant hyponatremia was associated with a 2.47-fold higher risk of death (HR = 2.47, 95% CI 1.53–3.99, p < 0.001).
Heavy alcohol group likely increases hyponatremia risk through multiple mechanisms: low-solute hypotonic intake (beer potomania), SIADH, cirrhosis-related effective volume depletion, and malnutrition. Our findings align with previous evidence suggesting that hyponatremia reflects both dilutional physiology and systemic decompensation.The strong correlation between hyponatremia and mortality indicates that sodium imbalance acts as a key mediator linking alcohol-related organ dysfunction to adverse outcomes. Thus, identifying and managing hyponatremia early may be critical to improving prognosis in heavy alcoholics.
In conclusion, hyponatremia is twice as frequent among heavy alcohol users and independently predicts higher mortality and prolonged hospitalization. Early detection and multidisciplinary correction strategies are crucial to improve outcomes in this population.
