Measurement for Parenchymal Stiffness of Renal Allograft using Transient Elastography in Patients after Kidney Transplantation

Certificate Output Instructions

For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".

To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".

Presented the abstract " "
(Abstract co-author(s): )

Back

E-Poster Presentation

During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.

Preparing your E-Poster

Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.

E-Poster Submission Deadline

Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.

E-Poster Format Requirements

PDF file
Layout: Portrait (vertical orientation)
One page only (Dim A4: 210 x 297mm or PPT)
E-Poster can be prepared in PowerPoint (one (1) PowerPoint slide) but must be saved and submitted as PDF file.
File Size: Maximum file size is 2 Megabytes (2 MB)
No hyperlinks, animated images, animations, and slide transitions
Language: English
Include your abstract number
E-posters can include QR codes, tables and photos

E-Poster

Abstract Title *

Measurement for Parenchymal Stiffness of Renal Allograft using Transient Elastography in Patients after Kidney Transplantation

Please follow the instructions below to input your abstract title.

Abstract titles should be brief and reflect the content of the abstract.

The title will not be accepted if it exceeds 25 words.
Type in CAPITAL LETTERS.
Lowercase may be used for abbreviations only, for example, mRNA.

Co-author 1

Kohei Unagami unagami.kohei@twmu.ac.jp Tokyo Women's Medical University Organ Transplant Medicine Tokyo Japan *

Co-author 2

Ayaka Saitoh saito.ayaka_2@twmu.ac.jp Tokyo Women's Medical University Organ Transplant Medicine Tokyo Japan -

Co-author 3

Kazuya Omoto omotokazuya@yahoo.co.jp Tokyo Women's Medical University Urology Tokyo Japan -

Co-author 4

Yu Kijima meyu10033@gmail.com Tokyo Women's Medical University Urology Tokyo Japan -

Co-author 5

Daigo Okada daigoing5@gmail.com Tokyo Women's Medical University Urology Tokyo Japan -

Co-author 6

Toshihito Hirai hirai.toshihito@twmu.ac.jp Tokyo Women's Medical University Urology Tokyo Japan -

Co-author 7

Tomokazu Shimizu shimizu.tomokazu@twmu.ac.jp Tokyo Women's Medical University Urology Tokyo Japan -

Co-author 8

Toshio Takagi takagi.toshio@twmu.ac.jp Tokyo Women's Medical University Urology Tokyo Japan -

Co-author 9

Junichi Hoshino hoshino.junichi@twmu.ac.jp Tokyo Women's Medical University Nephrology Tokyo Japan -

Co-author 10

Hideki Ishida ishida.hideki@twmu.ac.jp Tokyo Women's Medical University Tokyo Women's Medical University Tokyo Japan -

Co-author 11

Co-author 12

Co-author 13

Co-author 14

Co-author 15

Introduction

The evaluation of allograft-kidney fibrosis is very important for kidney transplant (KTx) management. Kidney biopsy has been cited as a method for evaluating interstitial fibrosis and tubular atrophy (IF/TA) of renal allograft, but it is very invasive and has shortcomings in terms of sequency and quantitation. Transient elastography (TE) is a device that mainly measures cirrhosis by transmitting shear waves of a certain frequency from the body surface under ultrasound. Originally, it was thought that it cannot be measured in organs deep from the body surface such as auto-kidneys, but it is thought that it can be measured in transplanted kidney located at iliac fossa.

Methods

A total of 530 recipients underwent living-donor kidney transplantation at our institution between 2001 and 2023, were included in this study. All of them were performed TE (FibroScan®expert630, Echosense Paris, France), TE measured parenchymal stiffness in a volume that approximated a cylinder of 10mm in width and 25-55mm in length by spleen stiffness measurement mode (Figure). The allograft kidney function, IT/TA by biopsy result, were compared and analyzed.

Results

The measurement of parenchymal stiffness was successful in 523 of 530 patients (98.3 %). For TE result, median stiffness of renal allograft parenchyma was 51.2 kPa. For the correlation with fibro scan median values, recipients’ serum creatinine level, eGFR, and IFTA showed statistically significant difference (p <0.01, in each). Further, when divided to 2groups (eGFR >40 and ≦40), allograft kidney age, renal allograft parenchyma, and recipients’ hemoglobin level showed significant difference (p <0.01).

Conclusion

Transplant-kidney function deterioration and IF/TA progression showed strong correlation with renal allograft parenchyma. For assessment of parenchymal stiffness of allograft, TE will be a very useful measurement.

Kewords