ASSOCIATION BETWEEN CYTOMEGALOVIRUS ANTIGENAEMIA AND POLYMERASE CHAIN REACTION RESULTS IN KIDNEY TRANSPLANT PATIENTS

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ASSOCIATION BETWEEN CYTOMEGALOVIRUS ANTIGENAEMIA AND POLYMERASE CHAIN REACTION RESULTS IN KIDNEY TRANSPLANT PATIENTS

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Co-author 1

Ayaka Saitoh saito.ayaka_2@twmu.ac.jp Tokyo Womens Medical University Department of Organ Transplant Medicine Shinjuku Japan *

Co-author 2

Kohei Unagami unagami.kohei@twmu.ac.jp Tokyo Womens Medical University Department of Organ Transplant Medicine Shinjuku Japan -

Co-author 3

Yu Kijima meyu10033@gmail.com Tokyo Womens Medical University Department of Urology Shinjuku Japan -

Co-author 4

Taketomo Nishikawa taketomo308070@med.mie-u.ac.jp Tokyo Womens Medical University Department of Organ Transplant Medicine Shinjuku Japan -

Co-author 5

Satoshi Takai sacchin_64@yahoo.co.jp Tokyo Womens Medical University Department of Organ Transplant Medicine Shinjuku Japan -

Co-author 6

Daigo Okada daigoing5@gmail.com Tokyo Womens Medical University Department of Urology Shinjuku Japan -

Co-author 7

Miyuki Furusawa hime@wf6.so-net.ne.jp Tokyo Womens Medical University Department of Organ Transplant Medicine Shinjuku Japan -

Co-author 8

Toshihito Hirai hirai.toshihito@twmu.ac.jp Tokyo Womens Medical University Department of Urology Shinjuku Japan -

Co-author 9

Kazuya Omoto omotokazuya@yahoo.co.jp Yochomachi clinic Department of Urology Shinjuku Japan -

Co-author 10

Tomokazu Shimizu shimizu.tomokazu@twmu.ac.jp Tokyo Womens Medical University Department of Organ Transplant Medicine Shinjuku Japan -

Co-author 11

Toshihito Takagi takagi.toshio@twmu.ac.jp Tokyo Womens Medical University Department of Urology Shinjuku Japan -

Co-author 12

Hideki Ishida hishida@twmu.ac.jp Tokyo Womens Medical University Department of Organ Transplant Medicine Shinjuku Japan -

Co-author 13

Co-author 14

Co-author 15

Introduction

Cytomegalovirus (CMV) infection is one of the most frequent complications of kidney transplantation (KTx). In recent years, CMV infection has been evaluated using polymerase chain reaction (PCR), although this is an excellent quantitative measure, its correlation with conventional CMV antigenaemia (AG) remains unclear. We evaluated the correlation between CMV pp65 AG and quantitative PCR assays.

Methods

At Tokyo Women’s Medical University Hospital, 26 specimens from five KTx recipients (CMV IgG status: four patients were negative, one patient was positive; Table 1) were tested simultaneously for CMV AG and quantitative CMV PCR assays. These specimens were collected from June 2023 to December 2024.

Results

In most tests, a linear association was observed between AG and the PCR results (Figure 1). As a result of deviating from this association, two specimens were taken from patient D, who already had CMV-IgG before KTx, and was considered as overestimated (Figure 1B, red spot).

Figure 1. Association between cytomegalovirus polymerase chain reaction (PCR; IU/mL) results logarithmic conversion and (a) antigenaemia, and (b) according to classification (1＝0, 2＝1, 3＝2~3, 4＝4~10, 5＝10~20, 6≧21)

Conclusion

Both CMV AG and quantitative CMV PCR assays, including CMV PCR on plasma, have clinical utility for diagnosis active disease cases and monitoring KTx recipients with first infection. However, a possibility of an overestimation in patients with CMV IgG positivity exists.

Kewords