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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Lupus podocytopathy (LP) is rare in lupus nephritis and have distinct features compared with traditional lupus nephritis (LN) pathologic changes. However, the immune mechanism of LP is still unclear.
LP cases were included in our cohort divided into three groups: minimal change disease (MCD), mesangial proliferation (MsP) and focal segmental glomerular sclerosis (FSGS). To reveal immune signatures of LP, we collected peripheral blood mononuclear cell (PBMC) samples from 4 LPs, 4 LNs of class III or IV and 5 healthy controls（HC）. Seurat (version 4.3.0.1) was used for differentially expressed gene analysis.
There were 2489 patients with biopsy-proven LN, diagnosed at the First Affiliated Hospital of Sun Yat-sen University from January 1, 1980 to September 1, 2023, and only 28 (1.1%) cases fulfilled the criteria of LP, including 20 MCD, 6 MsP and 2 FSGS. There was only 1 male, who was in FSGS, while all others were females. Their median age at renal biopsy was 30 years old. The median time of lupus duration was 2.5 months, while duration of renal disease was 1.5 months. Totally, there were 5 patients with a fever, 10 with joints pain and 10 with a rash. Six patients presented with AKI and all of them were in the MCD group. Our latest follow-up found that 2 patients died: one died 13 years after renal biopsy for sudden cardiac death, the other died 8 years after renal biopsy for kidney diseases. 1 patient reached end-stage renal disease (ESRD) 8 years after biopsy. 19/21 (90.5%) patients achieved remission but of which 10 relapsed (52.6%).
After quality control and filtering, a total of 84770 cells with 38284 genes were subjected to further analysis. All the cells were annotated into 6 cell types: T cell, B cell, natural killer (NK) cell, dendritic cell (DC), monocyte and platelet. By comparing the numbers and proportions of cell types among LP, LN and HC groups, we found that the percentage of T cell in LP was significantly higher than that in LN or HC. The number of B cell and DC in LP was significantly higher than in HC, while there was no significant difference compared with the LN group. For T cell, the fractions of the cells in each group revealed a significantly greatest population of cytotoxic CD8+ T cell in LP, which may reveal the special immune signatures of lupus podocytopathy.
Although LP is associated with a high remission rate, it carries a high risk of relapse. In addition, the long-term risks of ESRD and death indicated a not benign process and necessitate close follow-up. Moreover, peripheral blood immune profiling has revealed that cytotoxic CD8+ T cell may be the special immune signature of LP.
