ASSOCIATION BETWEEN TRIGLYCERIDE-GLUCOSE INDEX AND CORONARY ARTERY CALCIFICATION PROGRESSION POPULATION WITH MILD RENAL INSUFFICIENCY

 

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https://storage.unitedwebnetwork.com/files/1099/700daceaf3f8ec9ce4140aab22e06283.pdf
ASSOCIATION BETWEEN TRIGLYCERIDE-GLUCOSE INDEX AND CORONARY ARTERY CALCIFICATION PROGRESSION POPULATION WITH MILD RENAL INSUFFICIENCY

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Chung Hwan
Lee
Chung Hwan Lee 0131542@yuhs.ac Gangnam Severance Hospital, Yonsei University College of Medicine Division of Nephrology, Department of Internal Medicine, Seoul Korea (Republic of) *
Hyo Jeong Kim TOJEONG@yuhs.ac Gangnam Severance Hospital, Yonsei University College of Medicine Division of Nephrology, Department of Internal Medicine Seoul Korea (Republic of) -
Wooram Bae bwr@yuhs.ac Gangnam Severance Hospital, Yonsei University College of Medicine Division of Nephrology, Department of Internal Medicine Seoul Korea (Republic of) -
Jong Hyun Jhee JJHLOVE77@yuhs.ac Gangnam Severance Hospital, Yonsei University College of Medicine Division of Nephrology, Department of Internal Medicine Seoul Korea (Republic of) -
Hyeong Cheon Park AMP97@yuhs.ac Gangnam Severance Hospital, Yonsei University College of Medicine Division of Nephrology, Department of Internal Medicine Seoul Korea (Republic of) -
Hoon Young Choi hychoidr@yuhs.ac Gangnam Severance Hospital, Yonsei University College of Medicine Division of Nephrology, Department of Internal Medicine Seoul Korea (Republic of) -
 
 
 
 
 
 
 
 
 

Patients with chronic kidney disease (CKD) may be more likely to develop cardiovascular disease (CVD) complications than the general population. Quantity of coronary artery calcification (CAC) correlates with atherosclerotic plaque burden, and increased CAC indicates a substantially increased risk of cardiovascular events. This study aimed to evaluate the association between the triglyceride-glucose (TyG) index and CAC aggravation in patients with mild renal insufficiency (mRI) without diabetes.

This retrospective longitudinal study included adult participants who voluntarily underwent cardiac computed tomography at least twice between January 2006 and October 2018 (n=1,516). The TyG index was determined using ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). mRI was defined as 60 ≤ estimated glomerular filtration rate (eGFR) ≤ 90 mL/min/1.73m2, using the Chronic Kidney Disease Epidemiology Collaboration equation for eGFR calculation. CAC aggravation was defined as an increased follow-up CAC score. To evaluate the CAC aggravation risk, logistic regression analyses were performed.

The study included 1,516 patients, of whom 746 had mRI without diabetes. The CAC aggravation was significantly higher in participants with a higher TyG index (odds ratio [OR], 1.65; 95% confidence interval [CI], 1.27-2.15; P<0.001). After adjusting for age, sex, mean arterial pressure, hemoglobin, calcium × phosphorus, and potassium, the TyG index, as continuous variables or quartiles, was associated with increased CAC risk in participants with mRI compared with that of the lowest TyG quartile (OR, 1.42; 95% CI, 1.02-1.98; P=0.03, as continuous variables; OR 1.88, 95% CI, 1.11-3.19; P=0.03, vs. lowest quartile). The restricted cubic spline curve showed that the CAC risk increased at a TyG index value of 8.55. In the subgroup analysis among the participants with TyG index over 8.55, TyG index was independently associated with CAC aggravation risk. 

Among the population with mRI without diabetes, a higher TyG index positively correlated with CAC progression.

Kewords