Back
For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".
To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".
During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Paraneoplastic glomerulonephritis is a rare complication of a malignant tumor, with glomerular lesions that are not directly related to tumor burden, invasion or metastasis, but are induced by products of tumor cells. The diagnosis of paraneoplastic glomerulonephritis is challenging and often delayed, which can lead to significant morbidity and mortality.
In the literature reported in the world, ANCA associated vasculitis (AAV) occurs in 14-20% of paraneoplastic syndromes associated with renal tumors; of which 71% are clear-cells carcinoma. In Latin America there are no cohorts that evaluate the association of AAV and renal cell carcinoma.
Between May 2023 and April 2024 a case-series report was carried out by means of the revision of clinical records of patients who were admitted to the General Hospital of Mexico, with a requirement for kidney replacement therapy without data of chronicity and with studies lasting less than 2 months without alteration in BUN neither creatinine, so ultrasonographic scanning was performed presenting images suggestive of kidney tumor; due to rapidly progressive deterioration, ANCAS determination was performed with a positive result, confirming the tumor with tomography.
CASE 1: A 51-year-old man, admitted at hospital due to uremic syndrome and hyperkalemia, requiring placement of a hemodialysis catheter and kidney replacement therapy started. However, in laboratories of March 2023, creatinine and bun were identified without alteration. During hospitalization due to rapidly progressive deterioration, anti-neutrophil cytoplasmic antibodies were requested with positivity for anti-MPO. Because of the image in ultrasonographic scanning upon admission, tomography was requested to determine characteristics of the tumor with clear-cell renal carcinoma as most probable diagnosis. The kidney tumor was approached with partial nephrectomy, in July 2023, The pathology results showed clear cell renal cell carcinoma and the kidney biopsy reported active extracapillary proliferative glomerulonephritis of pauci-immune type, with focal and segmental sclerosis (scarring, glomerulonephritis associated with haunches, mixed class); Focal acute tubular injury with moderate regenerative changes of the epithelium, grade II interstitial fibrosis (30-40%); moderate arteriosclerosis. The glomerular morphological pattern and the result of the direct immunofluorescence study suggest the behavior of a small vessel vasculitis, a mixed class for glomerulonephritis associated with ANCAS.
CASE 2: A 56-year-old man, admitted at hospital due to uremic syndrome, deciding placement of a hemodialysis catheter and kidney replacement therapy was started. Due to clinic behavior of rapidly progressive glomerulonephritis, anti-neutrophil cytoplasmic antibodies were requested with positivity for anti-MPO. Because of the image in ultrasonographic scanning, tomography was requested to determine characteristics of the tumor with report of clear-cell renal carcinoma as most probable diagnosis. A kidney biopsy was performed, reporting active extracapillary proliferative glomerulonephritis of pauci-immune type, sclerotic class, grade II interstitial fibrosis.
CASE 3: A 44-year-old man with a diagnosis of PR3-positive ANCA-associated vasculitis (Granulomatosis with Polyangiitis) was referred to our nephrology service due to proteinuria, accompanied by worsening renal function. Kidney assessment revealed a kidney mass, and subsequent contrast-enhanced computed tomography (CT) demonstrated findings suggestive of renal cell carcinoma. A radical nephrectomy was performed, and histopathological examination confirmed clear-cell renal carcinoma. Concurrently, a renal biopsy was performed because of the kidney function deterioration and active urine sediment, and showed pauci-immune extracapillary proliferative glomerulonephritis, sclerotic class, with grade III interstitial fibrosis.
This mini-review of our three cases and the available literature reinforces that AAV patients carry a persistently increased risk of malignancy, including RCC, through both disease-related and therapy-related mechanisms. Recognition of atypical features, timely imaging, and structured surveillance are crucial. The intersection of vasculitis and cancer underscores the need for multidisciplinary management, balancing immunosuppression with oncologic safety, and tailoring long-term follow-up strategies to mitigate the dual burden of disease. With the introduction of newer therapeutic regimens and reduced cumulative exposure to alkylating agents, future epidemiological trends may shift, potentially altering the incidence and spectrum of malignancies observed in AAV.
