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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Chronic kidney disease (CKD) affects over 10% of the global population, and in advanced stages requires renal replacement therapies such as peritoneal dialysis (PD). Catheter-associated peritonitis remains the most frequent infectious complication, leading to hospitalization, catheter removal, and increased mortality. Conventional diagnostic methods, including microbiological culture take at least 24 to72 hours to provide results, delaying antimicrobial therapy and worsening outcomes. The aimara of this study is to develop a colorimetric sensor based on L-cysteine-functionalized silver nanoparticles (AgNPs) for the rapid detection of bacterial metabolites associated with peritoneal dialysis-related peritonitis, as a first step toward deployable sensor films for PD devices.
We conducted a prospective analysis at the Hospital General Regional 110 Oblatos, Instituto Mexicano del Seguro Social, Guadalajara, Mexico. Patients were categorized into two groups: those with peritonitis and controls (stable peritoneal dialysis without infection). Silver nanoparticles were synthesized using both chemical and green methods. Functionalization with L-cysteine (L-Cys-AgNPs) was optimized by adjusting pH, concentration, and reaction time. Characterization was performed using FTIR, TEM, and DLS to assess morphology, colloidal stability, and functionalization. The colorimetric response was tested against bacterial metabolites (H₂S, indole, amines) and phenolic compounds (gallic acid, caffeic acid, guaiacol, catechin, quercetin), as well as clinically relevant microorganisms (S. aureus, S. epidermidis, P. aeruginosa, E. coli). Negative controls included sugars and bovine serum albumin (BSA).
Functionalized L-Cys-AgNPs demonstrated a rapid (~10 seconds) and highly selective colorimetric response to bacterial metabolites and pathogens compared with controls, outperforming conventional diagnostic methods in detection speed. L-cysteine functionalization enhanced affinity and sensitivity toward bacterial compounds, allowing early discrimination between infected and non-infected samples.
We developed a rapid, selective, and low-cost colorimetric sensor with strong potential for early detection of peritoneal dialysis-associated peritonitis. This platform could represent a clinically useful innovation for infection surveillance and prompt management in PD patients.
