CARDIOVASCULAR EVENTS AFTER COVID-19 INFECTION IN KIDNEY TRANSPLANT RECIPIENTS: A CASE-CONTROL STUDY

 

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https://storage.unitedwebnetwork.com/files/1099/cc26ae05bd810d41e96c4a2c43db19e1.pdf
CARDIOVASCULAR EVENTS AFTER COVID-19 INFECTION IN KIDNEY TRANSPLANT RECIPIENTS: A CASE-CONTROL STUDY

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Gisele
Meinerz
Carolina Tagliari tagliaricarolina@gmail.com UFCSPA Graduation Program in Patology Porto Alegre Brazil -
Gisele Meinerz giselemeinerz@icloud.com UFCSPA Medical Clinical Department Porto Alegre Brazil *
Tainá Freitas Taina.sandes@gmail.com Portal da UFC - Universidade Federal do Ceará - Página Inicial Universidade Federal do Ceará (UFC) Nephrology Fortaleza Brazil -
Valter Garcia vdgarcia@gmail.com Santa Casa de Porto Alegre Nephrology and Kidney Transplant Porto Alegre Brazil -
Elizete Keitel elizetekeitel@gmail.com UFCSPA Graduation Program in Patology Porto Alegre Brazil -
 
 
 
 
 
 
 
 
 
 

Background: Kidney transplant recipients represent a population at increased risk for COVID-19–related complications. However, the long-term effects of SARS-CoV-2 infection on cardiovascular outcomes in this group remain poorly understood.

Objective: To assess the association between prior COVID-19 infection and the occurrence of cardiovascular events in kidney transplant recipients in 60 months follow-up.

Methods: This retrospective, observational, case-control study included 486 kidney transplant patients followed at two Brazilian hospitals. Participants were divided into two groups: cases (with confirmed previous COVID-19 infection) and controls (without infection history), with 243 individuals in each group. Clinical variables, incidence of cardiovascular events (acute myocardial infarction, stroke, angina, arrhythmia, thrombosis, hospitalization for heart failure), cardiovascular mortality, and combined outcomes (MACE) in different compositions (3-, 4-, and 5-point) were compared using odds ratio (OR) and 95% confidence interval (95% CI) analyses.


Results: A total of 486 patients were included, equally distributed between cases (n=243) and controls (n=243). The median age at transplantation was 40 (28–50) years, similar between the groups (p=0.973). Most participants were male (59.3% in both groups, p=1.000) and white (82.7% cases and 84.3% controls, p=0.880). Most donors were deceased (73%). The frequency of hypertension (77.7% cases and 79.0% controls; p=0.741), diabetes mellitus (11.9% cases and 14.8% controls; p=0.424) and retransplantation (14.8% cases and 10.7% controls; p=0.221) was high. No significant differences were found between cases and controls regarding isolated cardiovascular events or composite outcomes (MACE). However, when stratified by COVID-19 severity, hospitalization due to SARS-CoV-2 infection was significantly associated with worse composite cardiovascular outcomes (HR 12.9; 95% CI: 5.07–32.9; p < 0.001), as well as with diabetes (HR 2.09; 95% CI: 1.14–3.83; p = 0.017). Kidney graft survival was lower in severe cases (64.8%) compared with non-severe cases (88.7%) and controls (85.9%; p = 0.004). In multivariate analysis, hospitalization remained independently associated with reduced graft survival (HR 2.39; 95% CI: 1.37–4.19; p = 0.002), adjusted for age, gender, hypertension and diabetes.


HR of Major Cardiovascular Events in 60 months according to COVID-19 severity compared to controls


Conclusions: SARS-CoV-2 infection was not associated with increased cardiovascular mortality or MACE among kidney transplant recipients in long term analysis. However, COVID-19 severity was significantly related to poorer composite cardiovascular outcomes and decreased kidney graft survival in 60 months.

Kewords