EARLY POST-TRANSPLANT ANEMIA IDENTIFIES HIGH-RISK KIDNEY TRANSPLANT RECIPIENTS

 

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EARLY POST-TRANSPLANT ANEMIA IDENTIFIES HIGH-RISK KIDNEY TRANSPLANT RECIPIENTS

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Laura del Carmen
Fuentes-Mendez
Laura del Carmen Fuentes-Mendez laufuentesmendez@gmail.com Hospital General de Mexico Nephrology Mexico City Mexico *
Lucia Monserrat Pérez-Navarro lucymonsepn@hotmail.com Hospital General de Mexico Nephrology Mexico City Mexico -
Rafael Valdez-Ortiz rafavaldez@gmail.com Hospital General de Mexico Nephrology Mexico City Mexico -
 
 
 
 
 
 
 
 
 
 
 
 

Anemia is common after kidney transplantation and has been linked to inferior outcomes. Early post-transplant anemia (PTA) may reflect impaired erythropoietic recovery or subclinical allograft dysfunction. This study aimed to determine whether anemia detected at one month post-transplant independently predicts long-term graft survival.

A single-center retrospective cohort included adult kidney transplant recipients from 2012–2016 who survived at least one year post-transplant. Clinical and laboratory data were obtained from the institutional transplant registry at baseline and at 1, 3, 6, and 12 months. Early PTA was defined as hemoglobin ≤10.5 g/dL at one month. Patients were classified as anemic or non-anemic. The primary outcome was graft survival; secondary outcomes included patient survival and renal function decline. Multivariable Cox regression was performed to identify independent predictors of graft loss.

Sixty-four recipients were analyzed (mean follow-up 28.6 ± 11.4 months); 16 (25%) developed early PTA. Baseline features, including age, sex, donor type, cause of kidney failure, induction therapy, and immunosuppressive regimen, were comparable between groups. Renal function declined more steeply among anemic patients. At last follow-up, creatinine clearance was significantly lower in the anemic versus non-anemic group (58.1 ± 21.7 vs. 72.3 ± 18.3 mL/min; p = 0.013). Five-year Kaplan–Meier analysis showed inferior graft survival among anemic patients (log-rank p = 0.03) (Figure 1). On multivariable analysis, early anemia remained independently associated with graft loss (HR 12.6; 95% CI 1.5–15.7; p = 0.019). (Figure 1)  Mortality did not differ significantly between groups.

Early post-transplant anemia—affecting one in four recipients—was independently associated with long-term graft loss, regardless of baseline or immunosuppressive variables. These findings align with recent evidence showing PTA as a marker of chronic allograft injury rather than a mere consequence of impaired function. Given its high prevalence and the lack of transplant-specific anemia guidelines, early monitoring and correction of hemoglobin and iron parameters may represent a modifiable target to improve graft longevity. Prospective studies are needed to determine whether timely intervention during this early window can alter the trajectory of chronic allograft damage. The content presented in this abstract was submitted for other meetings.

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