CLINICAL OUTCOMES OF RENAL TRANSPLANTATION IN RECIPIENTS WITH ATHEROSCLEROTIC ILIAC ARTERIES: A SINGLE CENTRE STUDY.

 

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https://storage.unitedwebnetwork.com/files/1099/6950b59c1ed9d7c13bb6e5cf10d9e947.pdf
CLINICAL OUTCOMES OF RENAL TRANSPLANTATION IN RECIPIENTS WITH ATHEROSCLEROTIC ILIAC ARTERIES: A SINGLE CENTRE STUDY.

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Olalekan
Olatise
Olalekan Olatise oo.olatise@gmail.com Zenith Medical and Kidney Centre Department of Internal Medicine Abuja Nigeria *
Hyginus Ekwuazi hoekwuazi@gmail.com Zenith Medical and Kidney Centre Department of Surgery Abuja Nigeria -
Stephen Asaolu stephen.asaolu@gmail.com Zenith Medical and Kidney Centre Department of Clinical Research Abuja Nigeria - Sydani Institute for Research and Innovation, Sydani Group Research Abuja Nigeria
Aishat Shaibu shaibuaishatojone@gmail.com Zenith Medical and Kidney Centre Department of Clinical Research Abuja Nigeria -
Michael Muoka muokamichael@yahoo.com Zenith Medical and Kidney Centre Department of Clinical Research Abuja Nigeria -
Buniyameen Musa toseenbilly@gmail.com Zenith Medical and Kidney Centre Department of Surgery Abuja Nigeria -
Rex-ogbuku Williams rexogbukuw@gmail.com Zenith Medical and Kidney Centre Department of Surgery Abuja Nigeria -
Paul Olorunfemi drstar299@gmail.com Zenith Medical and Kidney Centre Department of Surgery Abuja Nigeria -
Isaac Odunfa odunfaisaac@yahoo.com Zenith Medical and Kidney Centre Department of Surgery Abuja Nigeria -
Adaku Olatise drateeo@gmail.com Zenith Medical and Kidney Centre Department of Internal Medicine Abuja Nigeria -
Odinaka Ikeugwoke Ikeugwokeody@gmail.com Zenith Medical and Kidney Centre Department of Radiology Abuja Nigeria -
Abubakar Umar zmkctransplant@gmail.com Zenith Medical and Kidney Centre Department of Surgery Abuja Nigeria -
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Renal transplantation is the most effective treatment for end-sage kidney disease (ESKD), offering superior survival and quality of life compared to dialysis. However, increasing prevalence of iliac artery atherosclerosis poses substantial surgical challenges, particularly in resource-limited settings where vascular imaging may not be a routine. We therefore set out to evaluate the clinical outcomes of renal transplantation in recipients with iliac artery atherosclerosis at a Nigerian transplant centre, focusing on prevalence, intraoperative challenges, surgical strategies and short-term outcomes.

A retrospective observational study was conducted with patients that had transplant between August 2023 and July 2024, and includes all adult ESKD patients with documented iliac artery atherosclerosis. Extracted data included sociodemographic data, comorbidities, intraoperative findings, and postoperative outcomes. Statistical analysis was carried out using Microsoft excel and SPSS version 27

A total of 162 patients had kidney transplantation within the study period. The incidence of iliac artery atherosclerosis was 54.87%. The average age of the patients was 51.26 years, 80.6% were males, and the commonest comorbidities were diabetes mellitus, hypertension and HIV. The average BMI was 24.49 kg/m2, while about 29.1% were either overweight or obese. The site of the atheromatous plaque were external iliac artery (69.4%), femoral artery (24.2%), common iliac artery (3.2%), while some patients had it in all the vessels (3.2%). Additionally, 79.0% were bilateral, 12.9% were right-sided, while 8.1% were left-sided plaques. Out of these, 69.4% were mild, 14.5% were moderate and 16.1% were severe atherosclerosis. During the surgeries, bleeding, thrombosis and slipped suture and re-anastomosis were observed in only one patient each. Findings in the immediate post operative period included delayed graft function (6.5%), acute rejection (8.1%), and re-exploration (8.1%). The 1-year patient and graft survival were 88.7% and 72.6% respectively.

Renal transplantation in recipients with iliac artery atherosclerosis is feasible and can achieve relatively satisfactory short-term patient and graft survival outcomes when managed with appropriate surgical expertise and intraoperative vigilance. Although the incidence of atherosclerosis was relatively high in this cohort, perioperative complications were infrequent, revealing the value of careful patient selection and meticulous operative technique. These findings highlight the need for routine preoperative vascular assessment and context-specific surgical planning, particularly in resource-limited settings where atherosclerotic disease burden is rising alongside increasing transplant rates.

Kewords