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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Acute kidney injury (AKI) is a frequent complication in patients with nephrotic syndrome (NS), with reported prevalences ranging from 20–30%. There are limited data regarding its behavior in patients with nephrotic-range proteinuria (NP). The objective was to determine the prevalence and factors associated with the development of AKI in this population.
A retrospective and analytical study was conducted in patients ≥18 years old with NS or NP who underwent renal biopsy at the Hospital General de México between 2012 and 2025. Cases with a histopathological diagnosis of primary glomerulopathy and KDIGO criteria for AKI were included. Clinical, biochemical, and histopathological variables were analyzed using univariate tests, multivariate logistic regression, and survival analysis through the Cox regression model.
A total of 260 patients were evaluated; 74 (29%) developed AKI. Associated factors included type 2 diabetes (50% vs. 24%; p<0.001), arterial hypertension (34% vs. 22%; p=0.039), serum creatinine >1.02 mg/dL (91% vs. 56%; p<0.001), eGFR <45 ml/min/1.73 m² (80% vs. 39%; p<0.001), and hemoglobin <12 g/dL (80% vs. 34%; p<0.001).
Histopathological analysis showed that AKI was associated with a higher proportion of sclerosed glomeruli, advanced fibrosis, and tubular-interstitial injury (p<0.001). In multivariate analysis, independent predictors were eGFR <45 ml/min/1.73 m² (OR=2.31; 95% CI: 1.01–5.30; p=0.047) and hemoglobin <12 g/dL (OR=5.04; 95% CI: 2.40–10.56; p<0.001).
In Cox regression, the presence of AKI was associated with mortality (HR=4.33) and the need for renal replacement therapy (RRT) during a 60-month follow-up (HR=6.87).
Nephrotic-range proteinuria represents a high-risk clinical phenotype for AKI, associated with more severe clinical and histopathological alterations. Anemia and baseline renal dysfunction were identified as independent predictors not only of AKI but also of mortality and the need for RRT. These findings underscore the importance of a comprehensive evaluation and the need for prospective studies to confirm their prognostic relevance.
