Back
For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".
To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".
During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
High rates of graft functional loss in kidney transplant recipients (KTR) increase healthcare costs, morbidity, and reduce quality of life. Sphingosine-1-phosphate (S1P), a metabolite of very long-chain saturated fatty acids (VLSFA-) sphingolipids which we previously found to be reduced in KTR, is mainly produced by erythrocytes and regulates inflammation, endothelial integrity, and oxygen delivery. Experimental and observational evidence suggests that higher S1P may protect against renal inflammation, hypoxia, and fibrosis—key features of graft vasculopathy and chronic graft failure. This study examined associations between circulating S1P, VLSFA, and chronic graft failure in stable KTR.
This prospective cohort study included 494 outpatient KTR with a functional graft of 1 year. Plasma S1P was measured with liquid chromatography–mass spectrometry. Plasma VLSFA were measured with gas chromatography coupled with a flame ionization detector. Univariate and multivariable linear regression analyses were used to assess the association between plasma VLSFA, plasma S1P and potential determinants. Bootstrapping mediation analysis was conducted according to the method by Preacher and Hayes. Cox regression analyses were used to prospectively study the associations of S1P with chronic graft failure.
The total cohort consisted of 494 stable outpatient KTR (55% male, median age 55 (45-63) years), included at a median time of 5.2 (1.8-12.3) years after transplantation. Median concentrations of circulating VLSFA and S1P were 1.28 ± 0.30 mol% and 265 (223-334) nmol/l, respectively. In cross-sectional analyses, total circulating VLSFA had the second-strongest association with circulating S1P among potential determinants next to hemoglobin (VLSFA: std. β = 0.13, P = 0.001; hemoglobin: std. β = 0.21, P < 0.001 in multivariable adjusted analyses). In non-anemic subjects, total VLSFA was most strongly associated with S1P among potential determinants, whereas the association with hemoglobin was no longer significant (Fig. 1A; VLSFA: Std. β = 0.18, P = 0.007; hemoglobin: Std. β = 0.07, P = 0.28). During a median (interquartile range) follow-up of 5.0 (3.3 – 5.6) years, 65 (13%) KTR experienced chronic graft failure. In prospective analyses, circulating S1P was inversely associated with chronic graft failure, with a hazard ratio (HR) (95% confidence interval) per 1-SD-increment of 0.64 (0.46 – 0.90), p < 0.01, independent of potential confounders. Mediation analyses showed that circulating S1P mediated 16% (P = 0.01) of the inverse association between hemoglobin and chronic graft failure (Fig. 1B).
In non-anemic KTR, circulating VLSFA had the strongest association with circulating S1P among potential determinants. Circulating S1P was inversely associated with chronic graft failure and partly mediated the inverse association between hemoglobin and chronic graft failure. Future studies should evaluate whether increasing intake of VLSFA-rich foods like peanuts can enhance circulating S1P, favorably modify risk factors, and ultimately reduce chronic graft failure in kidney transplant recipients.
