PRELIMINARY REVIEW OF CAKUT OTHER THAN POSTERIOR URETHRAL VALVES SEEN IN CHILDREN IN A TERTIARY HOSPITAL IN SOUTHWEST NIGERIA.

 

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https://storage.unitedwebnetwork.com/files/1099/9fba6eadcc418b09e013c79bf9128539.pdf
PRELIMINARY REVIEW OF CAKUT OTHER THAN POSTERIOR URETHRAL VALVES SEEN IN CHILDREN IN A TERTIARY HOSPITAL IN SOUTHWEST NIGERIA.

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Adebowale
Ademola
Adebowale Ademola dr_deboademola@yahoo.co.uk University College Hospital Ibadan Paediatrics Ibadan Nigeria *
Michael Alao mikefountains@yahoo.com University College Hospital Ibadan Paediatrics Ibadan Nigeria -
Janet Akinmoladun jaakinmoladun@yahoo.com University College Hospital Ibadan Radiology Ibadan Nigeria -
Kafilat Afolabi kafilatafolabi1@yahoo.com University College Hospital Ibadan Radiology Ibadan Nigeria -
Augustine Takure augusturoendo@gmail.com University College Hospital Ibadan Surgery Ibadan Nigeria -
Ogundoyin Olukayode kayogundoyin@yahoo.com University College Hospital Ibadan Surgery Ibadan Nigeria -
Adanze Asinobi adasinobi@yahoo.co.uk University College Hospital Ibadan Paediatrics Ibadan Nigeria -
Olayiwola Shittu obshittu@yahoo.com University College Hospital Surgery Ibadan Nigeria -
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Congenital anomalies of the kidneys and urinary Tract (CAKUT)are an important cause of morbidity and mortality among children globally. CAKUT is also the leading cause of end-stage kidney disease among children globally. There is limited information on CAKUT among children in many parts of sub-Saharan Africa, and this is worse regarding forms of CAKUT presentation other than posterior urethral valves. Data on CAKUT in low resource settings is critical for the designing strategies for early diagnosis, management and evaluation of outcomes. We hereby report the prevalence and incidence of CAKUT among in-patients seen at the University College Hospital Ibadan.

Retrospective study of incident and prevalent cases of CAKUT other than posterior urethral valves among children who were seen in the paediatric nephrology clinic, or who were managed as in-patients by the paediatric nephrology unit of University College Hospital Ibadan, Southwest Nigeria from the January - September 2025. Data was extracted from the paediatric nephrology database, ward and clinic registers and patient case records. All patients underwent abdominal ultrasound. CT urography and renal scintigraphy each was carried out in 4 patients (25%), while intravenous urography and micturating cystourethrogram was carried out in 2 and 1 patients respectively.

A total of 16 children with CAKUT other than posterior urethral valves were seen during the period. The age at presentation ranged from birth – 14 years, Median 1.5 months IQR 0.5-110 months.  There were 11 males. Abnormal antenatal ultrasound scans were reported in 11 (68.8%). An abdominal mass on palpation was reported in 11 patients.

The lesions were Left PUJO in 7(43.8%), Bilateral PUJO in 2, while 1 patient had isolated right PUJO. One patient had ectopic kidney in association with nephrotic syndrome. Table 1 shows anomalies that were identified.

Management included unilateral nephrectomy in one patient with Lt PUJO and unilateral nephrectomy and open pyeloplasty in another patient with bilateral PUJO. End-stage renal disease was not reported among the series


Table 1: Forms of Congenital anomalies of the Kidneys and urinary   Tract (CAKUT) and number of Patients


CAKUTNumber of Patients      n (%)
Left PUJO7 (43.8)
Bilateral PUJO2 (12.5)
Bilateral mild hydroureteronephrosis2
Right PUJO1
Right duplex kidney, with impaired drainage in the lower moiety  and right grade 5 VUR and dysplastic kidney1
Right PUJO with severe HN and Left VUR with mild to moderate HN1
Duplex left kidney with hydroureteronephrosis of the left upper pole moiety1

HN: Hydronephrosis   PUJO- Pelviureteric junction Obstruction, VUR: Vesicoureteral Reflux

Unilateral PUJO is the most common cause of CAKUT in this preliminary series. Support for the management of CAKUT in less well-resourced settings is needed in the areas of access to diagnostic investigations. Developments of local and multicentre CAKUT registries, may lead to improvement in awareness, and enhance the development of strategies to further improve the detection, management and outcomes.

Kewords