LIFESTYLE INTERVENTIONS USING DIGITAL APPS AND MEDICAL SERVICES FOR REDUCING CKD PROGRESSION: A SYSTEMATIC REVIEW AND META-ANALYSIS

 

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LIFESTYLE INTERVENTIONS USING DIGITAL APPS AND MEDICAL SERVICES FOR REDUCING CKD PROGRESSION: A SYSTEMATIC REVIEW AND META-ANALYSIS

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Naohiko
Fujii
Kanako Oka kanako.kitamura@gmail.com Osaka University Graduate School of Medicine Nephrology Suita, Osaka Japan -
Takuya Ohata xmate85@gmail.com Hyogo Prefectural Nishinomiya Hospital Rehabilitation Nishinomiya, Hyogo Japan -
Shungo Fukuda fukutchi@gmail.com Osaka University Graduate School of Medicine Nephrology Suita, Osaka Japan -
Shun Manabe shunmn5711@gmail.com Tokyo Women's Medical University Nephrology Tokyo Japan -
Junichi Hoshino hoshino.junichi@twmu.ac.jp Tokyo Women's Medical University Nephrology Tokyo Japan -
Yoshitaka Isaka isaka@kid.med.osaka-u.ac.jp Osaka University Graduate School of Medicine Nephrology Suita, Osaka Japan -
Naohiko Fujii nfujii-npr@umin.net Hyogo Prefectural Nishinomiya Hospital Nephrology Nishinomiya, Hyogo Japan *
 
 
 
 
 
 
 
 

Exercise therapy is increasingly being integrated into the management of non-dialysis-dependent (NDD-) CKD. While some studies suggest that exercise may help maintain GFR in the short term, the current evidence remains insufficient to establish its long-term effects. A major issue is low patient adherence to exercise routines, which highlights the need for methods to help sustain behavioral change. Although modern digital apps and healthcare services are expected to boost adherence, studies specifically evaluating their effectiveness in CKD exercise interventions are limited.

To address this gap, we conducted a systematic review to assess the impact of digital apps and healthcare services on kidney outcomes in CKD patients. The review utilized a search strategy based on the guidelines of the Japanese Society of Renal Rehabilitation published in 2018, covering studies from January 1, 1990, to December 31, 2023. Potential articles matched to the keyword list were extracted from the PubMed database. Two reviewers independently screened titles and abstracts to identify candidates for full-text analysis and data extraction. Meta-analyses were performed if there were a sufficient number of eligible studies (basically three or more). All statistical analyses were performed using Stata 17.0 (StataCorp LLC, TX, USA).

From 395 screened articles, nine studies assessing prespecified clinical outcomes (e.g., GFR, proteinuria, and albuminuria) were identified, with eight focusing on GFR changes in CKD stages G3–G4. Interventions varied, ranging from pedometers and traditional communication (phone, email) to digital devices (smartphones, tablets). The studies generally had a high risk of bias, lacked adequate blinding, and seldom used intention-to-treat analysis. GFR was estimated using serum creatinine (excluding cystatin C). A meta-analysis of seven studies found no significant intervention effect on GFR (+1.40 [95% CI: -1.87, +4.67] mL/min/1.73m²), nor did a subgroup analysis of short-term interventions (+2.79 [95% CI: -1.22, +6.80] mL/min/1.73m²). Furthermore, only three studies assessed proteinuria and albuminuria, yielding inconsistent findings. 

The evidence for digital and service-based exercise interventions in NDD-CKD patients is currently insufficient to form definitive conclusions. While small RCTs suggest potential GFR preservation and a low risk of clinical harm (no reported deterioration), the psychological burden and patient discomfort associated with these novel treatments are unstudied. The increasing ubiquity of digital devices is expected to fuel a rise in clinical trials, which should substantially enhance the evidence base.

Kewords