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Pregnancy is a remarkable physiological event, even in healthy women. It brings significant changes to the body, requiring complex adaptations in nearly every organ system to support the developing fetus. These changes are even more profound and challenging in women with chronic kidney disease undergoing hemodialysis. Pregnancy in such cases is rare and considered high-risk, both for the mother and the fetus. Despite these challenges, successful pregnancies can occur under close medical supervision. This report presents two such rare and extraordinary cases of women who became pregnant and successfully gave birth while on maintenance hemodialysis.
Case 1
The first case involves a 36-year-old woman with chronic kidney disease secondary to vesicoureteral reflux, who had been under regular follow-up in our clinic for approximately 18 years. Her baseline serum creatinine levels ranged from 1.8 to 2.0 mg/dL. She had been married for about five years and was not using contraception, as the possibility of pregnancy was considered extremely low.
A spontaneous pregnancy was detected at 8 weeks of gestation. The patient and her family were informed about the potential complications, including the high risk of miscarriage. It was explained that, to continue the pregnancy, intensive hemodialysis, at least six sessions per week, each lasting four hours, would be required. After discussing the risks and expectations, the family opted to proceed with the pregnancy.
A right internal jugular hemodialysis catheter was placed, and intensive hemodialysis was initiated. The patient was jointly followed by the nephrology and perinatology teams, with evaluations performed at least once a month. The fetal growth remained consistent with gestational age throughout the pregnancy.
Case 2
The second case concerns a 31-year-old woman with no known history of kidney disease, who presented at 10 weeks of spontaneous pregnancy. Her baseline creatinine level was unknown; however, upon presentation, it was measured at 1.7 mg/dL. Renal ultrasound revealed that kidney dimensions were at the lower limit of normal.
The patient and her family were counseled about potential pregnancy-related and renal complications. As in the first case, intensive hemodialysis, six days per week, was recommended, and the family chose to proceed with the pregnancy and initiate hemodialysis therapy.
A right internal jugular dialysis catheter was placed, and intensive dialysis was started. Follow-up continued jointly with perinatology at least monthly. At 38 weeks of gestation, the patient delivered a healthy infant via cesarean section. The newborn required no medical support and was breastfed.
At 35 weeks, spontaneous labor began, and the patient delivered vaginally. The newborn did not require any medical support and was exclusively breastfed from birth. The mother's serum creatinine remained at 5.0 mg/dL postpartum. Although she maintained adequate urine output, hemodialysis therapy was continued due to advanced renal insufficiency.
Postpartum, the mother’s creatinine levels improved. Hemodialysis was continued for approximately 20 days after delivery, after which it was discontinued as renal function stabilized.
Both pregnancies requiring hemodialysis were successful and ended with deliveries of healthy babies without any complications.
These two cases demonstrate that even in the presence of chronic kidney disease requiring hemodialysis, a successful pregnancy and healthy delivery are possible with close multidisciplinary monitoring and intensive dialysis therapy. Proper counseling and adherence to individualized treatment plans are essential to optimize both maternal and fetal outcomes.