A 54-YEAR-OLD MALE WITH CHEST PAIN AND SEVERE HYPOCALCEMIA: A CASE REPORT OF PRIMARY HYPOPARATHYROIDISM, AT THE AGA KHAN HOSPITAL KISUMU- KISII MEDICL CENTER

 

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https://storage.unitedwebnetwork.com/files/1099/cecc5ca530586f4ad3ae2d97411bf952.pdf
A 54-YEAR-OLD MALE WITH CHEST PAIN AND SEVERE HYPOCALCEMIA: A CASE REPORT OF PRIMARY HYPOPARATHYROIDISM, AT THE AGA KHAN HOSPITAL KISUMU- KISII MEDICL CENTER

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ANN
MUTUGI
ANN MUTUGI annmutugi91@gmail.com Agha Khan Hospital Kisumu Department of Medicine Kisumu Kenya *
BEN LOMATAYO ben.lomatayo@akhskenya.org Agha Khan Hospital Kisumu Department of Medicine Kisumu Kenya -
Shadrack Shabanji sshabanji@kisiiuniversity.ac.ke Kisii University Department of Medicine Kisii Kenya -
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Chest pain is a rare manifestation of hypocalcemia. Primary hypoparathyroidism, characterized by low parathyroid hormone levels, high serum phosphorous, low serum calcium and normal magnesium levels, represents a rare and uncommon cause.

Patient concerns: A 54-year-old East African male with no comorbidities, no significant family history and no surgical history, presented with acute and severe left-sided chest pain radiating to the left shoulder and jaw for two hours mimicking acute coronary syndrome. Acute coronary syndrome, renal failure, pulmonary embolism, aortic dissection, pseudo and pseudopseudo-hypoparathyroidism were ruled out. Chvostek and Trosseau’s signs were positive, other physical exam was unremarkable. Laboratory findings were as follows: Serum calcium levels were low at 1.14 mmol/l, serum phosphorous was high at 2.78 mmol/l, parathyroid hormone level was low at 4pg/ml, and serum magnesium levels were normal at 0.73mmol/l.

Diagnosis: Primary hypoparathyroidism based on clinical presentation, low parathyroid hormone levels, low serum calcium levels, and elevated serum phosphorous. Urine electrolytes were not measured due to cost constraints.

Interventions: Intravenous 10% calcium gluconate bolus, oral calcium and sevelamer.

Outcomes: Resolution of chest pain and neuro-muscular irritability immediately after initiation of treatment. Subsequently serum calcium levels normalized to 2.4 mmol/l, phosphorous reduced to 1.3 mmol/l, magnesium remained normal at 0.68 mmol/l while parathyroid hormone levels remained low at 4pg/ml .

Take-home lessons: This case underscores the importance of recognizing atypical presentations of hypocalcemia and primary hypoparathyroidism.

Kewords