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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
A recent American Heart Association (AHA) presidential advisory has defined the cardovascular-kidney-metabolic (CKM) sydrome as an adverse and progressive interplay of obesity and key metabolic alterations, chronic kidney disease (CKD) and cardiovascular diseases (CVD). Research has suggested higher mortality rates for women in CKM stage 2 and 3. We sought to examine the relationship between sex and mortality rates with worsening CKM stages.
Using 2001-2020 data from the National Health and Nutrition Examination Survey (NHANES), we categorized US adults (aged ≥20 years) into the five CKM stages: stage 0: no CKM risk factors, stage 1: excess or dysfunctional adiposity (overweight or obesity, abdominal obesity, prediabetes), stage 2: metabolic risk factors and CKD (hypertension, hypertriglyceridemia, diabetes, metabolic syndrome, KDIGO moderate-to-high risk CKD), stage 3: subclinical CVD (10-year PREVENT CVD risk ≥20%), and stage 4: clinical CVD and CKD (diagnosed congestive heart failure, cardiovascular disease, myocardial infarction, coronary heart disease, stroke, KDIGO very high risk CKD). Using a cox proportional hazard model we examined all-cause mortality in CKM stages using sex as a mediator, and adjusting for demographics, income, insurance status, current smoking, and physical activity.
The cox proportional hazards model showed males had a higher HR of mortality (HR: 2.07-5.65) compared to females (HR: 1.0-4.48) at every stage of CKM. However, when we calculate HRs with individual references for each sex, then the mortality is relative to each sex’s baseline (stage 0). In this case, with each increasing stage the mortality among females becomes higher with increasing CKM stage compared to men.
Overall mortality is generally higher for males than females, regardless of what CKM stage they are in. However, with the individual sex strata, women appear to have a steeper rise in mortality risk with rising CKM stage relative to men, and that difference increases with increasing stage of CKM. Underlying biologic reasons for these observations require further investigation.
