SEROPOSITIVITY AGAINST SARS-CoV-2 AND COVID-19 INFECTION IN HEMODIALYSIS PATIENTS VACCINATED AGAINST THE DISEASE

 

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SEROPOSITIVITY AGAINST SARS-CoV-2 AND COVID-19 INFECTION IN HEMODIALYSIS PATIENTS VACCINATED AGAINST THE DISEASE

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EDWIN EDUARDO
PEREZ TEJADA
EDWIN EDUARDO PEREZ TEJADA eduardoperez3@yahoo.es ESSALUD LIMA LIMA Peru *
JESSICA BRAVO ZUÑIGA eduardoperez3@yahoo.es ESSALUD LIMA LIMA Peru -
ANSELMA PARDO VILLAFRANCA eduardoperez3@yahoo.es ESSALUD LIMA LIMA Peru -
CARLOS TAPIA ZERPA eduardoperez3@yahoo.es ESSALUD LIMA LIMA Peru -
MARIA TERESA LOPERA QUINTANILLA eduardoperez3@yahoo.es ESSALUD LIMA LIMA Peru -
EDUARDO LUNA VICTORIA DIAZ eduardoperez3@yahoo.es ESSALUD LIMA LIMA Peru -
PERCY SOTO BECERRA eduardoperez3@yahoo.es ESSALUD LIMA LIMA Peru -
PERCY HERRERA AÑAZGO eduardoperez3@yahoo.es NEFROLOGO LIMA LIMA Peru -
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This study evaluated the effectiveness of the anti–COVID-19 vaccine in a long-term chronic hemodialysis population by measuring vaccine-induced antibody levels, and assessing the incidence of infection, hospitalization, intensive care admission, or death due to SARS-CoV-2 infection at 6 and 9 months following vaccination.

EVALUATED PATIENTS. SEROPOSITIVITY AGAINST SARS-CoV-2 AND COVID-19 INFECTION IN HEMODIALYSIS PATIENTS VACCINATED AGAINST THE DISEASE

A total of 168 patients from the Centro Nacional de Salud Renal (CNSR) of EsSalud who had received the COVID-19 vaccine were included. Antibody levels were measured in March 2022 and June 2022. Serum samples were collected prior to the dialysis session, during the second session of the week, to determine vaccine antibody titers at six and nine months after the second vaccine dose. Clinical data were obtained from the electronic medical records of patients with ESRD on hemodialysis at the CNSR of EsSalud. Post-vaccination COVID-19 infection was identified, and data were collected on hospitalization, intensive care unit (ICU) admission, and mortality.

The final study population comprised 159 patients, with a mean age of 54 ± 14 years. The most common etiologies of chronic kidney disease were hypertension and diabetes (48%). Antibody levels, expressed in BAU/mL, declined between the first and second sampling periods, with a median of 8,500 BAU/mL at the first measurement and 5,495 BAU/mL at the second. Fifteen patients (9.5%) developed mild COVID-19 infection after vaccination; none required hospitalization or ICU admission, and there were no deaths due to COVID-19. The analysis of post-vaccination infection probability by antibody level (BAU/mL) showed that infection risk persisted up to 10,000 BAU/mL, with no significant reduction beyond this threshold.



CHARACTERISTICS ACCORDING TO VACCINATION AND COVID-19 EVENT OF THE  POPULATION OF PATIENTS IN HEMODIALYSIS CNSR ESSALUD

LEVELS OF ANTI COVID 19 VACCINE ANTIBODIES  POPULATION OF PATIENTS IN HEMODIALYSIS CNSR ESSALUD  FIRST AND SECOND SAMPLING

CHARACTERISTICS OF THE STUDY POPULATION SEROPOSITIVITY AGAINST  SARS-COV-2 AND COVID -19 INFECTION IN THE POPULATION PATIENTS ON  HEMODIALYSIS CNSR ESSALUD VACCINATED AGAINST THE DISEASE

COVID 19 EVENTS ACCORDING TO POPULATION CHARACTERISTICS PATIENTS IN  HEMODIALYSIS CNSR ESSALUD

VACCINE ANTIBODY LEVELS  ANTI COVID 19 CNSR HEMODIALYSIS POPULATION FIRST AND  SECOND SAMPLING


AGE OF POPULATION OF PATIENTS IN HEMODIALYSIS CNSR  ESSALUD AND PROBABILITY OF INFECTION


Antibody levels showed a non-significant decline between the third and sixth months of follow-up, with median titers of 8,500 BAU/mL and 5,495 BAU/mL, respectively. None of the patients who developed COVID-19 required hospitalization or intensive care.

Kewords