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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Patients with chronic kidney disease (CKD) are at increased risk of developing cognitive impairment due to various mechanisms related either to traditional factors (age, education level, social relationships, comorbidities) or those specifically linked to CKD (vascular calcifications, chronic inflammation, anemia, malnutrition, uremic toxins retention, dialysis). Moreover, neurocognitive disorders (NCD) are associated with higher morbidity and worse prognosis in CKD. Therefore, we aimed to assess the prevalence and determinants of NCD in adults with CKD.
A cross-sectional study was conducted, enrolling 210 consecutive adults with CKD in stable clinical condition who were admitted to a tertiary nephrology referral hospital. Patients with acute kidney injury, kidney graft, known psihiatric disorders or addictions, Alzheimer’s disease, or age below 18 years were excluded. All selected subjects provided written informed consent prior to any study procedures.
Cognitive performance was assessed using the Mini-Mental State Examination (MMSE). A score between 19 and 23 was interpreted as mild NCD, while a score ≤18 was considered major NCD. Demographic, psychosocial and medical history data were collected from the patients’ records, along with laboratory results (estimated glomerular filtration rate [eGFR] calculated from serum creatinine, urinary protein-to-creatinine ratio, serum hemoglobin, albumin, calcium, phosphate, intact parathyroid hormone, and C-reactive protein).
The study group consisted mainly of. women (72%), with a median age of 66 (55;73) years and median eGFR of 32 (11;56) ml/min. CKD etiology was evenly distributed between glomerular diseases, vascular and tubulointerstitial nephropathies. The main comorbidities were arterial hypertension (82%), carotid artery atherosclerosis (85%), cerebrovascular disease (28%), ischemic heart disease (24%), and diabetes mellitus (32%). Most subjects subjects were married (70%) and had a medium level of education (57%).
The median MMSE score was 28 (25;30). Nearly one in five subjects (19%) were identified as having some degree of NCD (MMSE score ≤23), predominantly mild (92% scored between 19 and 23). Subjects with NCD were older, had lower education levels, and more frequently exhibited atherosclerosis in cerebral and coronary territories, as well as anemia. No significant differences were observed regarding the prevalence of diabetes mellitus, eGFR, proteinuria, or parameters of mineral metabolism, nutritional and inflammatory status.
In logistic regression analysis, older age, lower hemoglobin, and the presence of ischemic heart disease were independent predictors of impaired cognitive status.
These findings support the role of older age and systemic atherosclerosis as the main determinants of NCD in chronic kidney disease, while the kidney function itself did not show an independent association with cognitive status. In addition, anemia (reflected by lower hemoglobin levels) appears to negatively impact cognition in CKD patients.
