IMPLEMENTATION AND OUTCOMES OF A CONTINUOUS QUALITY IMPROVEMENT PROGRAM IN CONTINUOUS RENAL REPLACEMENT THERAPY AT TERTIARY-CARE HOSPITALS

 

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IMPLEMENTATION AND OUTCOMES OF A CONTINUOUS QUALITY IMPROVEMENT PROGRAM IN CONTINUOUS RENAL REPLACEMENT THERAPY AT TERTIARY-CARE HOSPITALS

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Yazmin Alejandra
Mercado Hernández
Yazmin Alejandra Mercado Hernández yazale1992@hotmail.com Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Nefrología y Metabolismo Mineral Mexico City Mexico *
Mario Alejandro Mendez Morales mariomendezhgm@gmail.com Hospital General de México Dr. Eduardo Liceaga Nefrología Mexico City Mexico -
Pablo Enrique Galindo Vallejo galindozip@gmail.com Hospital General de México Dr. Eduardo Liceaga Nefrología Mexico City Mexico -
Olynka Vega Vega olynkavega@hotmail.com Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Nefrología y Metabolismo Mineral Mexico City Mexico -
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Quality metrics (QMs) are fundamental tools used to measure, monitor, and evaluate clinical practice across different healthcare settings. The implementation of continuous quality improvement programs (CQIPs) has been reported to enhance these QMs in patients undergoing continuous renal replacement therapy (CRRT). The aim of this study was to compare the degree of goal achievement in CRRT QMs before and after the sequential implementation of a CQIP in two university hospitals.

Study phases of the multicenter study

This ambispective study was divided into three periods (Figure 1): Period 1 (retrospective, 2016–2019), before CQIP implementation in Hospital 1; Period 2 (prospective, 2020–2023), after CQIP implementation in Hospital 1; and Period 3 (prospective, 2024–2025), following the initiation of a CRRT program in Hospital 2 with the CQIP. The CQIP included the use of regional citrate anticoagulation (RCA) and a structured continuing education program for nursing and medical staff responsible for CRRT. Clinical and technical data were collected, QMs were calculated, and comparisons were made across the periods.

Quality metric targets in CRRT achieved during the three evaluation periods

Goals achieved in QM on CRRT during the three evaluated periods

A total of 209, 412, and 377 CRRT sessions were performed in 59, 93, and 89 patients during Periods 1, 2, and 3, respectively (Table 1). RCA was used in 45.6% and 77% of the sessions in Periods 2 and 3, respectively. The median filter lifespan increased from 36.5 hours in Period 1 to 64 hours in Period 2 and 81 hours in Period 3. The proportion of filters with a lifespan >60 hours rose from 23% in Period 1 to 54.5% in Period 2 and 71% in the last period. The proportion of sessions with a delivered-to-prescribed dose ratio >80% increased from 84% to 88% and up to 94%, respectively. Achievement of the ultrafiltration goal (>80%) was 66%, 63%, and 76% across the three periods. The percentage of sessions with downtime <10% was 65.5%, 70%, and increased to 90.6% in the last period. The rate of therapy-related adverse events was 8% in the first period, increased to 32% in the second, and decreased again to 8% in the third period. Overall, the percentage of goals achieved per period showed a marked improvement in the third period compared with the first and second.

The implementation of a CQIP in CRRT, as well as its integration from the initiation of a new program, was associated with substantial improvements in filter lifespan and compliance with key QMs. These findings suggest a more efficient use of resources and potential optimization of care for critically ill patients undergoing CRRT.

This abstract has been accepted for presentation at the American Society of Nephrology (ASN) Kidney Week 2025, to be held in November 2025 in Houston, Texas.

Kewords