CLINICAL, RADIOLOGICAL, AND GENOTYPIC CORRELATES IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE: A CROSS-SECTIONAL STUDY

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Abstract Title *

CLINICAL, RADIOLOGICAL, AND GENOTYPIC CORRELATES IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE: A CROSS-SECTIONAL STUDY

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Co-author 1

Sree Bhushan Raju Devaraju drsreebhushan@gmail.com Nizams Institute of Medical Sciences (NIMS) Department Of Nephrology Hyderabad India *

Co-author 2

Sri Sai Sumanth Nayani sumanth.nayani@gmail.com NIMS Nephrology Hyderabad India -

Co-author 3

Mayank Chauhan mank143chauhan@gmail.com NIMS Nephrology hyderabad India -

Co-author 4

Haard Barot haardbarot@gmail.com NIMS nephrology Hyderabad India -

Co-author 5

Nayan Poddar nayan.poddar@gmail.com NIMS nephrology Hyderabad India -

Co-author 6

Payal Gaggar payalgaggar04@gmail.com NIMS Nephrology Hyderabad India -

Co-author 7

Ravi Tej Madipalli ravitej.madipalli@gmail.com NIMS nephrology Hyderabad India -

Co-author 8

Co-author 9

Co-author 10

Co-author 11

Co-author 12

Co-author 13

Co-author 14

Co-author 15

Introduction

Autosomal Dominant Polycystic Kidney Disease (ADPKD) shows marked variability in clinical presentation and progression, influenced by genetic, radiological, and environmental factors. Limited data are available from South India integrating these parameters for comprehensive characterization.

Methods

In this cross-sectional study, 106 adult patients with clinically or radiologically diagnosed ADPKD were evaluated. Clinical details, laboratory data, and imaging findings were collected. Total kidney volume (TKV) and height-adjusted TKV (htTKV) were measured by MRI. Correlations between Phenotype, htTKV, and estimated glomerular filtration rate (eGFR) were analyzed.

Results

The mean age was 44.32 ± 11.29 years; 67 were males. Hypertension was present in 56 patients, and hepatic cysts in 52. Median eGFR was 41.0 mL/min/1.73m², and mean htTKV was 1277.46±1492.83 mL/m. Total ESRD patients 15 , Mean Ht TKV in eGFR <60 ml/min/1.73m2 was 603.68±282.99. Mean Ht TKV in eGFR > 60 ml / min/ m2 was 1726.65±1784.08. In our study among ESRD patients, females showed higher mean Ht TKV than males

Conclusion

This study highlights the heterogeneity of ADPKD in South India. Larger htTKV are associated with poorer renal function. Combined clinical, radiological, and genetic evaluation may improve early risk stratification and individualized care in ADPKD.

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