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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Protein-energy wasting (PEW) is a multifactorial metabolic derangement frequently occurring in chronic kidney disease (CKD) patients, particularly dialysis. Understanding the pathophysiological interplay between metabolic, inflammatory, and oxidative determinants of PEW in early CKD stages may help in preventing progression, reduce hospitalizations, and improve survival. Early detection may enable interventions to slow progression and improve outcomes before dialysis.We aim to determine the relationship between metabolic syndrome (MetS), inflammation, and oxidative stress with PEW in patients with CKD stages 2 to 5 (Pre dialysis).
A cross-sectional, observational study was conducted on 224 pre-dialysis CKD patients (stages 2–5), recruited from nephrology outpatient clinic. Clinical and biochemical parameters were evaluated. Anthropometric and dietary were taken. Blood sugar profile, levels of insulin resistance using HOMA-IR was done. We estimated serum levels of pro-inflammatory cytokines, Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-α), and anti-inflammatory cytokine Interleukin-10 (IL-10), biomarker of oxidative stress- malondialdehyde (MDA), and antioxidants – superoxide dismutase (SOD) and glutathione reductase (GR). PEW was diagnosed based on ISRNM criteria. Statistical analysis was performed using SPSS version 27.0, with multivariate logistic regression models to determine associations.
PEW was present in 45% of our pre-dialysis CKD cohort. The prevalence of PEW significantly increased with increasing CKD stages. The multivariate regression analysis revealed that MetS (Adjusted OR = 0.137, p = 0.012) was inversely associated with PEW, indicating a protective relationship. Insulin resistance demonstrated a strong positive association (OR = 2.332, p = 0.002). Among inflammatory markers, elevated TNF-α (Adjusted OR = 1.101, p = 0.003) and CRP (OR = 1.107, p = 0.03) were significantly associated with increased PEW risk, whereas IL-10 showed a negative association (OR = 0.882, p = 0.04). Oxidative stress markers also played a critical role, decreased activities of GR (Adjusted OR = 1.128, p < 0.001) and SOD (Adjusted OR = 0.07, p < 0.001), alongside elevated MDA (Adjusted OR = 1.285, p < 0.001) which were significantly associated with PEW.
Our findings emphasize on the multifactorial pathogenesis of PEW in early to advanced CKD, implicating the pivotal roles of presence of MetS, inflammation, and oxidative stress. Targeting these interlinked inflammatory and oxidative pathways and personalized interventions may offer novel strategies for nutritional and metabolic management to mitigate PEW progression in pre-dialysis CKD patients.
