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E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
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Abstract titles should be brief and reflect the content of the abstract.
The Chilean Health System is defined as a system based on Primary Care where the Cardiovascular Health Program (CHP) aims to reduce premature morbidity and mortality from cardiovascular (CV) diseases through patient-centred care in primary health settings. Chronic kidney disease (CKD) is a major comorbidity in this population. Since 2024, KDIGO guidelines recommend the Kidney Failure Risk Equation (KFRE) to estimate the risk of CKD progression. However, little is known about sex and gender differences in CKD progression and CV profiles among primary care patients in Latin America. Objective: To analyse CV risk factors associated with CKD progression in adults enrolled in a CHP in Santiago, Chile, exploring sex and gender disparities in clinical and metabolic profiles.
A historical cohort of adult patients enrolled at the CHP in a Family Health Centre in Santiago (March 2023–June 2025) was analysed. Descriptive and analytical statistics were applied using registry data (age, sex, diabetes, hypertension, BMI, waist circumference, lipids profile, HbA1c, eGFR and KFRE). Comparisons between men and women were performed using Student t test , Mann – Witney U tests with p < 0.05 considered significant.
A total of 4,983 patients were included (63% women, mean age 63 ± 14.7 years). Men showed higher prevalence of hypertension (81.6% p=0.02) and type 2 diabetes (48.6% p<0.001), while women had higher rates of overweight/obesity (77.5% p=0.011), central obesity (83% p<0.0001), dyslipidaemia (72% p<0.0001), low HDL (57% p=0.017) and metabolic syndrome (40% p<0.0001). CKD was diagnosed in 428 patients (8.6%) in the following distribution: 5.4% G3a, 2.2% G3b, 0.6% G4, and 0.4% G5. High HbA1c (≥7%) was associated with lower eGFR <45ml/min/1.73m² (OR = 1.92 CI95% 1.19–3.10). Median KFRE scores were significantly higher in men vs. women at 2 years (1.3 % vs. 0.8 %, p<0.001) and 5 years (3.9 % vs. 2.5 %, p<0.001), respectively (Table 1).
Men exhibited higher risk of CKD progression based on KFRE despite similar age and diabetes prevalence. Women showed greater metabolic risk burden but lower predicted renal progression. By implementing KFRE at the CHP offers a useful tool for improving monitoring information and clinical decision-making in primary health care, involving sex analysis.
Funding: Regular Fondeyt #1231909.