CYTOKINE ADSORBER IN SEPSIS ASSOCIATED AKI

 

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CYTOKINE ADSORBER IN SEPSIS ASSOCIATED AKI

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Sudheer
Pandey
Sudheer Pandey sudhirp947@gmail.com Marengo Asia hospital Nephrology Faridabad India *
Ambika Sharma ambikasharma305@gmail.com Marengo asia hospital Nephrology Faridabad India -
Sidharth Yadav sidharthnephro@gmail.com Marengo asia hospital Nephrology Faridabad India -
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Sepsis-associated AKI (SA-AKI) is a major cause of ICU mortality. Cytokine adsorption with CytoSorb® during CRRT may help reduce the inflammatory load and stabilize hemodynamic. We compared outcomes in patients treated with CRRT ± CytoSorb®.

Retrospective study (Jan 2024 – Sep 2025) including 52  ICU patients with SA-AKI requiring CRRT. 

Group A (n=22): CRRT + CytoSorb® & Group B (n=30): CRRT alone. 

Variables: SOFA score, vasopressor dose, lactate, urine output, RRT independence, 28-day mortality were analysed. All patient received standard sepsis care as per surviving sepsis campaign guideline’s

Both group were comparable in age, sex, infection source, and illness severity

Parameter 

Group A

Group B

P-Value

↓ NE dose (%)

61 ± 20

33 ±25

0.02

↓ Lactate (mmol/L)

4à1.8

3.9à3

0.03

Urine (ml/Day)

850à 1650

870à1180

0.04

RRT free by day 7

45

27

0.11

SOFA(imorovement)

2.6 ±1.2

1.1 ±0.8

0.01

28-day mortality(%)

41

57

0.19

CytoSorb® use with CRRT in SA-AKI improved hemodynamic stability, lactate clearance, and urine output, with a trend toward better renal recovery and survival.Though the mortality difference was not statistically significant, early integration may optimize outcomes in severe sepsis. Larger multicentre studies warranted to confirm these findings and refine patient selection criteria in Indian ICUs

Kewords