IMPACT OF DONOR SEX, AGE, AND BIOLOGICAL RELATIONSHIP ON RECIPIENT KIDNEY FUNCTION THREE MONTHS AFTER KIDNEY TRANSPLANTATION AT TERTIARY REFERRAL HOSPITAL IN YOGYAKARTA, INDONESIA

 

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IMPACT OF DONOR SEX, AGE, AND BIOLOGICAL RELATIONSHIP ON RECIPIENT KIDNEY FUNCTION THREE MONTHS AFTER KIDNEY TRANSPLANTATION AT TERTIARY REFERRAL HOSPITAL IN YOGYAKARTA, INDONESIA

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Nicolaus L. P.
Rungngu
Iri Kuswadi irikuswadi@yahoo.com FKKMK UGM Nephrology and Hypertension Departement Yogyakarta Indonesia -
R. Heru Prasanto heruprasanto@yahoo.com FKKMK UGM Nephrology and Hypertension Departement Yogyakarta Indonesia -
Metalia Puspitasari puspitasarimetalia@gmail.com FKKMK UGM Nephrology and Hypertension Departement Yogyakarta Indonesia -
Yulia Wardhani yulia.wardhani@gmail.com FKKMK UGM Nephrology and Hypertension Departement Yogyakarta Indonesia -
Danny Pratama Kuswadi danny.pratama.k@gmail.com FKKMK UGM Nephrology and Hypertension Departement Yogyakarta Indonesia -
Dwita D Adyahrini dwita.adyahrini@mail.ugm.ac.id FKKMK UGM Nephrology and Hypertension Departement Yogyakarta Indonesia -
Siti Nur Rohmah siti.nur.r@ugm.ac.id FKKMK UGM Nephrology and Hypertension Departement Yogyakarta Indonesia -
Nicolaus L. P. Rungngu lemp_pr@yahoo.com FKKMK UGM Fellow Student Nephrology and Hypertension Departement Yogyakarta Indonesia *
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Kidney allograft outcomes are strongly influenced by donor characteristics. Factors such as donor age, sex, and biological relationship may influence graft function after transplantation. This study sought to assess the relationship between donor characteristics and kidney allograft function three months after transplantation in tertiary referral hospital, Yogyakarta, Indonesia.

A retrospective cohort study was carried-out using data from living donor kidney transplantations conducted from 2023 to 2025 at tertiary referral Hospital, involving a total of thirty-six donor–recipient pairs. Donor variables (age, sex, and biological relationship) and ischemia-related factors were collected from medical records. Recipient kidney function was analyzed three months after transplantation based on estimated glomerular filtration rate (eGFR) values and serum creatinine levels. Statistical analyses employed Mann–Whitney and Kruskal-Wallis tests to explore the association between donor characteristics and graft function.

The mean donor age was 39.5 ± 10.9 years, with 72.2% male and 66.7% non-related donors. At three months, the mean recipient eGFR was 68.4 ± 23.2 mL/min/1.73 m² and the mean serum creatinine was 1.39 ± 0.47 mg/dL. A significant relationship was identified between donor sex and allograft performance; recipients who received kidneys from male donors exhibited improved renal function, reflected by higher eGFR and lower creatinine values (p = 0.022 and p = 0.014, respectively). No significant associations were observed between donor age or biological relationship and graft outcomes (p > 0.05), and no meaningful correlations were identified with recipient sex and blood type-related parameters.

Kidneys from male donors demonstrated superior short-term functional outcomes after transplantation. In this single-center study conducted at tertiary referral Hospital, Yogyakarta, donor age and biological relationship showed minimal influence on early allograft function.

Kewords