PREVALENCE OF GASTROINTESTINAL SYMPTOMS AND QUALITY OF LIFE IN PATIENTS WITH END STAGE RENAL DISEASE ON MAINTENANCE HAEMODIALYSIS AT KENYATTA NATIONAL HOSPITAL.

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Abstract Title *

PREVALENCE OF GASTROINTESTINAL SYMPTOMS AND QUALITY OF LIFE IN PATIENTS WITH END STAGE RENAL DISEASE ON MAINTENANCE HAEMODIALYSIS AT KENYATTA NATIONAL HOSPITAL.

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Co-author 1

Brenda Juma Brendaakinyi21@gmail.com University of Nairobi Internal Medicine Nairobi Kenya *

Co-author 2

Seth Mcligeyo mcligeyo@yahoo.com University of Nairobi Internal Medicine Nairobi Kenya -

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Introduction

Gastrointestinal symptoms (GIS) are regularly reported in end-stage renal disease (ESRD) patients undergoing haemodialysis (HD) and are associated with poor nutritional status and negative impact on quality of life (QOL) with subsequent mortality and morbidity.

Methods

A total of 165 patients with ESRD on maintenance HD completed two self-administered questionnaires: Gastrointestinal Symptom Rating Scale (GSRS) and Gastrointestinal Quality of Life index (GIQLI) which measures GIS and QOL respectively

Results

Overall 137/165 (83.0%) of patients with ESRD reported at least one of the following GIS: Indigestion 75.9%, abdominal pain 70.1%, constipation 59.1%, reflux 46.7%, diarrhoea 36.5%. Quality of life was significantly worse in participants with GIS than in participants without symptoms: Participants (n = 137) who reported at least one gastrointestinal symptom (GSRS score >1) had significantly lower GIQLI total score than those (n =28) who did not report any GIS (91.2 ± 24.2 vs 128.4 ± 12.5; P < 0.001). Chronic glomerulonephritis and duration of dialysis were associated with poor QOL in those with GIS. However, age, gender, BMI, hypertension, and diabetes mellitus did not have any significant association with QOL.

Conclusion

Gastrointestinal symptoms are highly prevalent among patients with ESRD undergoing maintenance HD and these patients also experienced significantly poor quality of life than patients with no GIS. These findings strengthen the need for emphasizing symptomatic management and improving the QOL hence long-term prognosis for ESRD patients with GIS.

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