DIETARY FIBER INTAKE AND RISK OF ALL-CAUSE MORTALITY IN KIDNEY TRANSPLANT RECIPIENTS

 

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https://storage.unitedwebnetwork.com/files/1099/30211cf7c7a6d0061563ddbdf1bda307.pdf
DIETARY FIBER INTAKE AND RISK OF ALL-CAUSE MORTALITY IN KIDNEY TRANSPLANT RECIPIENTS

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Firas F.
Alkaff
Sovia Salamah s.salamah@umcg.nl University Medical Center Groningen Department of Internal Medicine Groningen Netherlands -
Firas F. Alkaff f.f.alkaff@umcg.nl University Medical Center Groningen Department of Internal Medicine Groningen Netherlands * Faculty of Medicine, Universitas Airlangga Department of Anatomy, Histology, and Pharmacology Surabaya Indonesia
Stephan J.L. Bakker s.j.l.bakker@umcg.nl University Medical Center Groningen Department of Internal Medicine Groningen Netherlands -
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Despite successful transplantation, kidney transplant recipients (KTRs) are at higher risk of premature mortality than in the age- and sex-matched general population. This warrants a search for potentially modifiable factors to improve the survival of KTR. Previous studies in the general population and in patients with chronic kidney disease have shown that higher dietary fiber intake is associated with a lower risk of mortality. However, this has not been explored in KTR. Therefore, this study aims to evaluate the association between dietary fiber intake and mortality in KTR.

We used data from KTRs with a functioning graft for ≥1 year after transplantation that were enrolled in the prospective TransplantLines Food and Nutrition Biobank and Cohort Study. Fiber intake was determined using the food frequency questionnaire. Adequate dietary fiber intake was defined as a consumption of ≥ 25g/day. Physical activity was based on The Short QUestionnaire to ASsess Health-enhancing physical activity (SQUASH). Multivariable Cox regression analyses were performed to evaluate the association between dietary fiber intake and all-cause mortality, and the results were presented as hazard ratio [95% confidence interval (HR [95%CI]). All p <0.05 was considered to be statistically significant.

A total of 638 KTRs (44% female, median 6 years after transplantation, mean eGFR 52 ml/min/1.73m2) were included in the analyses. Of them, 197 (30.8%) had adequate dietary fiber intake. KTR with adequate dietary fiber intake had lower mean body mass index (26.1 ± 4.4 kg/m2 vs 26.9 ± 5.0 kg/m2, p = 0.028), lower median triglyceride level (1.60 [IQR 1.21-2.23] mmol/l vs 1.71 [IQR 1.28-2.39] mmol/l, p = 0.045), and lower median C-reactive protein level (1.4 [IQR 0.5-3.8] mg/l vs 1.7 [IQR 0.8-4.9] mg/l, p = 0.017). During a median follow-up of 5.4 years (IQR 4.8–6.1), 132 (20.7%) KTRs died. Higher dietary fiber intake was associated with a lower risk of all-cause mortality (HR [95%CI] per SD increase = 0.82 [0.69-0.99]), and the association remained significant independent of adjustment for potential confounders (Table). When categorized based on the dietary fiber intake adequacy, adequate dietary fiber intake was associated with a lower risk of all-cause mortality (HR [95%CI] = 0.68 [0.59-0.91], p = 0.010), and the association remained robust independent of adjustment for potential confounders (Table).

Dietary fiber intake may be a potentially modifiable factor to improve the KTR survival. Interventional trials are warranted to confirm the potential effect of dietary fiber intake in improving survival among KTR.

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