“IMPACT OF DIALYSIS DURATION ON POST-TRANSPLANT OUTCOMES: A COMPARATIVE STUDY OF KIDNEY TRANSPLANT RECIPIENTS WITH DIALYSIS VINTAGE LESS THAN AND GREATER THAN ONE MONTH”

 

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https://storage.unitedwebnetwork.com/files/1099/6f2b49c2d8349e6baab3622522371a00.pdf
“IMPACT OF DIALYSIS DURATION ON POST-TRANSPLANT OUTCOMES: A COMPARATIVE STUDY OF KIDNEY TRANSPLANT RECIPIENTS WITH DIALYSIS VINTAGE LESS THAN AND GREATER THAN ONE MONTH”

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KATHAN
CHUDGAR
KATHAN CHUDGAR kathanc1050@gmail.com JASLOK HOSPITAL AND RESEARCH CENTRE NEPHROLOGY MUMBAI India *
ASHAY SHINGARE ashayshingare@yahoo.co.in JASLOK HOSPITAL AND RESEARCH CENTRE NEPHROLOGY MUMBAI India -
MADAN M BAHADUR madan.bahadur@gmail.com JASLOK HOSPITAL AND RESEARCH CENTRE NEPHROLOGY MUMBAI India -
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Kidney transplantation is the preferred treatment for ESRD(End Stage Renal Disease), offering better survival and quality of life than dialysis. Dialysis duration prior to transplantation influences outcomes, as prolonged dialysis can cause inflammation, vascular calcification, malnutrition, and HLA sensitization, adversely affecting graft and patient survival. Pre-emptive transplantation improves graft function, reduces delayed graft function, and enhances long-term outcomes. The effects of very short dialysis (<1 month) remain underexplored. This study compares post-transplant outcomes in recipients with dialysis ≤1 month versus >1 month, focusing on graft function, patient survival, and complications. Objectives: To compare post-transplant outcomes in kidney transplant recipients based on pre-transplant dialysis duration (≤1 month vs. >1 month), focusing on graft function, patient survival, graft failure, rejection and infection.

This retrospective comparative study was conducted at tertiary care hospital to evaluate the impact of dialysis duration on post-transplant outcomes.  Kidney transplant recipients, including both living and deceased donor transplants, were included. Patients were categorized into two groups: Group A (≤1-month dialysis) and Group B (>1-month dialysis). Demographic data, cause of ESRD, donor type, comorbidities, and dialysis duration were collected. Post-transplant outcomes assessed included graft function, patient survival, graft failure, rejection and infective complications. A p-value <0.05 was considered statistically significant.



A total of 59 kidney transplant recipients were analyzed (7 with dialysis ≤1 month, 52 with >1 month). Overall, median age was 36 years, and 78% were male, with no significant intergroup differences. Parents (47%) and spouses (22%) were the most common donors. Hypertension (92%) and diabetes (19%) prevalence was similar. Chronic glomerulonephritis and unknown etiology were the most frequent native kidney diseases (p = 0.046). Most transplants were from living donor (95%) with hemodialysis as the modality (100%). Median dialysis duration was 14 days in the early group versus 360 days in the late group (p < 0.001). Induction therapy, baseline immunosuppression, and preoperative rituximab use were comparable. Overall rejection occurred in 19% (29% early vs 17% late, p = 0.6), graft failure in 1 (14%) -early vs 7 (13%) -late, and death in 0 (0%)- early vs 6 (12%)- late. Infectious complications occurred in 59%, primarily UTIs, pneumonia, and viral infections. Median serum creatinine was similar at follow-up (1.24 vs 1.40 mg/dL, p = 0.5).

Kidney transplant recipients with ≤1 month of dialysis had outcomes similar to those with longer dialysis, including graft function, rejection, mortality, and infections. Findings support early transplantation to curtail dialysis-related complications. Trends toward better graft function and fewer complications, including acute rejection, death and time to graft failure were observed in early transplant group, highlighting the need of timely referral. A short durations dialysis (≤1 month) prior to transplant may be as helpful as pre-emptive transplant, though the study is limited by a small sample size.

Kewords