CHANGING TRENDS OF GLOMERULAR DISEASES OVER TWO DECADES: KIDNEY BIOPSY DATA OF TWO DECADES

 

Certificate Output Instructions

For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".

To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".

 

 

Certificate Background

   

Presented the abstract " "
(Abstract co-author(s):  )

 

 

  Back
E-Poster Presentation

During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center. 

Preparing your E-Poster

Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.

​E-Poster Submission Deadline

Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.​

E-Poster Format Requirements
  • PDF file
  • Layout: Portrait (vertical orientation)
  • One page only (Dim A4: 210 x 297mm or PPT)
  • E-Poster can be prepared in PowerPoint (one (1) PowerPoint slide) but must be saved and submitted as PDF file.
  • File Size: Maximum file size is 2 Megabytes (2 MB)
  • No hyperlinks, animated images, animations, and slide transitions
  • Language: English
  • Include your abstract number
  • E-posters can include QR codes, tables and photos
 
CHANGING TRENDS OF GLOMERULAR DISEASES OVER TWO DECADES: KIDNEY BIOPSY DATA OF TWO DECADES

Please follow the instructions below to input your abstract title.

Abstract titles should be brief and reflect the content of the abstract.

  • The title will not be accepted if it exceeds 25 words.
  • Type in CAPITAL LETTERS.
  • Lowercase may be used for abbreviations only, for example, mRNA.
Sowrabha
Rajanna
Sowrabha Rajanna sourabha.rajanna@gmail.com St John's Medical College Nephrology Bangalore India *
Manjunath S Shetty drmanjunathsshetty@yahoo.com JSSAHER Nephrology Mysore India -
Sajad Ahamed sajad.me2@gmail.com JSSAHER Bioinformatics Mysore India -
Narayan Prasad narayan.nephro@gmail.com SGPGI Nephrology Lucknow India -
 
 
 
 
 
 
 
 
 
 
 

The increasing incidence of Chronic Kidney Disease and its adverse impact on the individual and society is vast. To mitigate the risk factors of CKD it is pertinent to know the causes of CKD in a given population as genetics, environmental factors, affordability and accessibility to health  determine the occurrence and progression of CKD. India lacks a single, unified national kidney biopsy registry due to a multitude of reasons.Here we show the changing trends of glomerular disease from a single centre captured between 2002 to 2023

This was an ambispective study undertaken at Nephrology department in a tertiary medical college, Southern India

Deidentified kidney biopsy data from a single centre which caters to five surrounding districts  was extracted from the electronic medical records after approval from the institute ethics committee.A total of 3864 biopsies between the period January 2002 to December 2023 were recorded on EpiCollect5 platform with a predesigned questionnaire.

Clinical details as available in the biopsy form, adequacy of tissue and histopathological diagnosis ( Light microscopy and Immunofluorescence) was noted.Any secondary diagnosis was also noted Electron microscopy was not available.Repeat biopsies in the same patient if any was taken as a single entity. Statistical analysis was done by SPSS software


Diabetic Nephropathy was the commonest glomerular disease 12.7% (490) across the spectrum of 22 years. It was followed by Minimal Change Disease (MCD) 9.6%(371) ,IgAN 9.5%(369), Membranous nephropathy(MN) 8.8%(342)  FSGS 8.6%(333) and Lupus nephritis 5.7%(222)


Agewise distribution

388 biopsies were done under the age of 18 years with MCD being the commonest 24%, followed by lupus 12.6% and FSGS 11.6%

3245 biopsies were done in the age group of 18-65 years and the commonest was Diabetic Nephropathy  13.8% followed by IgAN 10% MN  9.7%

231 biopsies were done over the age of 65 years and Diabetic nephropathy was the commonest at 12.7% followed by MCD 9.6% IgAN 9.5% and MN 8.8%


Trends over two different decades

1141 biopsies were conducted between 2002 to 2012 and 2727 biopsies between 2013-2023


Increase in incidence was noted with Diabetic Nephropathy (3.4% to 16.5%) IgAN (6.7% to 10.7%) Lupus Nephritis(3.1% to 6.9%) Infection related glomerulonephritis (1.5% to 5.1%) Chronic Interstitial Nephritis (2.7 % to 5.8%)

Decrease in incidence was noted with MCD (14.3% to 7.6%) MN (9.1% to 8.7%) FSGS (11.7%to 7.3%) and Acute Interstitial Nephritis  (6.4% to 4.6%)



We present the data of 3864 kidney biopsies done from 2002 to 2023. 


Diabetic Nephropathy is the leading cause of CKD in India in our study.  The four fold increase in incidence of diabetic nephropathy can be due to rising incidence of diabetics, change in biopsy practices by treating nephrologists with more patients getting biopsied for an accurate diagnosis and increased accessibility of nephrology services.


Other glomerular diseases which showed an uptick were IgAN and lupus nephritis.

Juvenile lupus incidence was high and is the second most common cause of glomerular disease after MCD in the pediatric population. Also alarming is the increase in CIN without a definitive cause. CKDu needs to be a high suspicion in this population


Membranous Nephropathy showed a decreasing trend and this could be due to availability of non invasive techniques for diagnosis. MCD and FSGS were less noted, perhaps due to better categorisation of histological patterns.


We are limited by a single centre data and inter observer variability of histopathology. However this study provides insights to the past and current glomerular diseases in Indian population


Kewords