Postoperative myocardial remodeling and functional status in patients with chronic kidney disease and mitral valve disease, undergoing surgical correction

 

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https://storage.unitedwebnetwork.com/files/1099/73f4dbdab838f58511a1b946262cbdac.pdf
Postoperative myocardial remodeling and functional status in patients with chronic kidney disease and mitral valve disease, undergoing surgical correction

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Elena
Efremova
Irina Lyapina zavirina@mail.ru Scientific research institute for complex issues of cardiovascular diseases Department of clinical cardiology Kemerovo Russia -
Elena Drew e.tolpekina.v@mail.ru Scientific research institute for complex issues of cardiovascular diseases Department of clinical cardiology Kemerovo Russia -
Olga Barbarash olba@mail.ru Scientific research institute for complex issues of cardiovascular diseases Department of clinical cardiology Kemerovo Russia -
Elena Efremova lena_1953@mail.ru Ulyanovsk State University Department of Therapy and Occupational Diseases Ulyanovsk Russia *
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One of the causes of heart failure is valve disease. Chronic heart failure leads to chronic kidney disease. AIim of study to evaluate the association between disease course characteristics and the nature of postoperative cardiac remodeling with the presence of chronic kidney disease (CKD) in patients, hospitalized for surgical correction of mitral valve (MV) disease.

The study included 148 patients with acquired non-infectious MV diseasehospitalized for surgical correction with cardiopulmonary bypass. The median age was 61,5 [51,3; 67,0] years, with an almost equal proportion of women and men: 70 (47,3%) and 78 (42,7%). Patients underwent clinical and anamnestic data analysis, transthoracic echocardiography with speckle-tracking assessment of right and left ventricular deformation. A six-minute walk test was performed to assess the functional status of the patients. Patients were divided into groups: Group 1 – patients with CKD stages 3a–4 (n=55), Group 2 – patients without CKD or with CKD stage below 3a (n=93). The contribution of moderate-to-severe CKD to the nature of myocardial remodeling and the course of the disease was assessed.

Patients with CKD stages 3a-4 were older (p=0,007), more often had combined mitral valve disease (p=0,003) and rhythm disturbance such as atrial fibrillation/flutter (p=0,001) than patients in group 2. In the early postoperative period, patients in group 1 more often had atrioventricular block of grade 2-3: 7 (12,7%) vs 2 (2,2%), p=0,013. Patients in group 1 had a larger indexed volume of the left and right atria (p=0,042 and p=0,007) before surgery. The presence of CKD stages 3a-4 is associated with a decrease in the ejection fraction and right ventricular fractional area change in the preoperative period by the B-coefficient of -7,759 (p=0,021) and by the B-coefficient of -7,047 (p=0,045), respectively. Before the MV correction and on the 30th day after the surgery, patients in group 1 were characterized by a smaller tricuspid annular plane systolic excursion (p=0,005 and p=0,026). One month after the surgery patients with CKD stages 3a-4 covered a significantly shorter distance of the six-minute walk test than patients in group 2: 362,3 [303,4; 421,1] m vs 449,4 [408,48 – 490,28] m, p=0,013.


Patients with CKD stages 3a-4 who underwent surgical correction of MV are characterized by less favorable clinical characteristics and structural and functional changes in the myocardium, as well as a higher risk of developing postoperative complications such as atrioventricular block.

Kewords