RENAL COORDINATOR REFERRAL FOR RENAL REPLACEMENT THERAPY PLANNING AT EGFR 9–14 ML/MIN/1.73 M² REDUCES URGENT DIALYSIS STARTS: EVIDENCE TO REFINE GUIDELINE PRACTICE POINTS

 

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https://storage.unitedwebnetwork.com/files/1099/d59e84c6f0eaaea0580ae7b03439c0c9.pdf
RENAL COORDINATOR REFERRAL FOR RENAL REPLACEMENT THERAPY PLANNING AT EGFR 9–14 ML/MIN/1.73 M² REDUCES URGENT DIALYSIS STARTS: EVIDENCE TO REFINE GUIDELINE PRACTICE POINTS

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Han Wei
Tiew
Han Wei Tiew tiewhw@gmail.com Khoo Teck Puat Hospital Renal Medicine Singapore Singapore *
Cathrine May Ching Kong kong.cathrine.mc@nhghealth.com.sg Khoo Teck Puat Hospital Renal Medicine Singapore Singapore -
Janice Tze Huay Ho ho.janice.th@nhghealth.com.sg Khoo Teck Puat Hospital Renal Medicine Singapore Singapore -
Allen Yan Lun Liu liu.allen.yl@nhghealth.com.sg Khoo Teck Puat Hospital Renal Medicine Singapore Singapore -
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KDIGO and KDOQI guidelines recommend initiating access planning at an eGFR of 15–20 mL/min/1.73 m². These are issued only as practice points, based on expert consensus or simulation modelling. We evaluated whether earlier referral to a renal coordinator (RC) reduces urgent dialysis initiation in a real-world cohort.

We retrospectively analysed 282 patients with end-stage kidney disease who initiated dialysis at a tertiary hospital between 2022 and 2024. All patients had established nephrology follow-up. The primary outcome was planned versus unplanned dialysis initiation. Logistic and Cox regression analyses were used to examine associations between referral timing to RC, baseline eGFR, and unplanned dialysis starts, adjusting for age, sex, ethnicity, aetiology of kidney disease, Charlson comorbidity index, and dialysis initiation within 90 days of RC review.

Overall, 79.8% (n = 225) underwent RC review before dialysis initiation. Event rates differed by chronic kidney disease (CKD) stage: among patients with CKD stage IV, 63.3% (31/49) had unplanned dialysis, compared with 84.1% (191/227) among those with CKD stage V. Kaplan–Meier analysis showed a shorter median time from RC review to dialysis initiation in unplanned versus planned dialysis (126 vs. 337 days, p < 0.001). Late referral to RC (within 90 days of dialysis initiation) independently predicted unplanned dialysis (OR 4.21, 95% CI 1.58–11.25, p = 0.004), while CKD stage IV at RC review was a protective factor (OR 0.36, 95% CI 0.15–0.89, p = 0.026). In Cox regression, referral at eGFR ≤ 9 mL/min/1.73 m² increased the risk of unplanned dialysis (HR 2.22, 95% CI 1.10–4.50, p = 0.027). Sensitivity analysis at eGFR ≤ 8 mL/min/1.73 m² showed a non-significant trend (HR 2.02, 95% CI 0.93–4.39, p = 0.078). Referral to RC at eGFR > 15 mL/min/1.73 m² showed no significant effect (HR 1.54, 95% CI 0.79–2.98, p = 0.205).

Early RC referral at an eGFR of approximately 9–14 mL/min/1.73 m² was associated with fewer urgent dialysis starts, even among patients already under nephrology care. These findings provide outcome-based evidence to complement KDIGO/KDOQI practice points and support embedding RC referral at eGFR 9–14 as a pragmatic standard while awaiting prospective trials.

Kewords