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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
There are limited reports on the role of urinary biomarkers in the diagnosis/ prognosis of children with ureteropelvic junction obstruction (UPJO). The aim is to document the utility of carbohydrate antigen (CA 19-9), neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule (KIM-1) in the diagnosis and prognosis of children with UPJO.
IEC approval number – IEC/NI/22/Jul/83-63. Controls were normal children, while non-obstructive dilatation (NOD) were children whose hydronephrosis resolved during follow-up. Study group included children with UPJO who worsened on ultrasound/ renogram or those who became symptomatic and underwent pyeloplasty. Urinary biomarkers NGAL, KIM-1, and CA19-9 were measured in controls and NOD at one point. Whereas in study group, samples were collected before pyeloplasty, at 6-weeks, and 6-months post pyeloplasy. Surgical outcomes were assessed by anteroposterior diameter of pelvis on ultrasound, drainage pattern on renogram and the reduction of biomarkers.
The urine CA 19‐9, NGAL, and KIM-1 levels were significantly higher (P=0.001) in the UPJO group than NOD and controls. Receiver operating characteristic analysis of CA 19‐9 revealed a urine biomarker cutoff of 95 U/mL for diagnosing UPJO (sensitivity 95/100; specificity 96/100; AUC 0.99). Combining all three biomarkers (specificity of 99.29% and sensitivity of 62% )or combining USG parameters with individual biomarkers increased the diagnostic ability of the biomarkers. Urinary CA 19-9, NGAL and KIM-1 levels showed a significant fall following pyeloplasty (p=0.001) at 6 weeks and 6 months post-op period. Urinary CA 19-9 is superior to NGAL and KIM-1 in identifying children with UPJO. Biomarker levels dropped significantly after a successful pyeloplasty, suggesting their role in prognosis. This present study establishes the utility of biomarkers in the diagnosis and prognosis of children with UPJO. Further larger studies are warranted.
Urinary CA 19-9 is superior to NGAL and KIM 1 in identifying children with UPJO. Combining all three biomarkers/ combining USG APD with individual biomarkers showed an increase in the diagnostic ability of the biomarker panel. Resolution of hydronephrosis is associated with rapid post-operative fall of urinary biomarker levels suggesting good efficacy of them as a prognostic tool after surgery.
