THE ASSOCIATION BETWEEN DIALYSIS DURATION AND LIPID PROFILE IN CKD PATIENTS

 

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THE ASSOCIATION BETWEEN DIALYSIS DURATION AND LIPID PROFILE IN CKD PATIENTS

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Ricky
Virnardo
Ricky Virnardo ric_vir_014@yahoo.co.id Universitas Syiah Kuala Nephrology Banda Aceh Indonesia *
Nadi Syah Putra nadisyahputra440@gmail.com Universitas Syiah Kuala Nephrology Banda Aceh Indonesia -
Riyandy Pratama pratamariyandy1@gmail.com Universitas Syiah Kuala Nephrology Banda Aceh Indonesia -
Era Muliana era.muliana1973@gmail.com Universitas Syiah Kuala Nephrology Banda Aceh Indonesia -
Desi Salwani desi.salwani@usk.ac.id Universitas Syiah Kuala Nephrology Banda Aceh Indonesia -
Abdullah Abdullah abdullah_sawang@yahoo.co.id Universitas Syiah Kuala Nephrology Banda Aceh Indonesia -
Maimun Syukri maimun_62@usk.ac.id Universitas Syiah Kuala Nephrology Banda Aceh Indonesia -
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Dislipidemia in CKD was characterized by high triglycerides and related to atherosclerosis, which leads to cardiovascular disease. Latest recommendations from Kidney Disease Improving Global Outcome (KDIGO) recommend adding statin for CKD patients aged> 50 years old or with cardiovascular risk. It's clearly shown that dyslipidemia was a major concern in CKD patients, but there is no clear evidence on how the duration of dialysis affects lipid profiles.

A cross-sectional study was performed on hemodialysis patients. Samples were collected by consecutive sampling from outpatients and inpatients who were undergoing chronic hemodialysis in dr. Zainoel Abidin Hospital, Banda Aceh. Samples were collected from October to December 2020. Inclusion criteria were patients aged over 18 years old,  undergoing hemodialysis for at least 6 months, and willing to participate in research. Patients with severe sepsis, malignancy, autoimmune disease, or on steroid treatment were excluded from this study.  The duration of dialysis was collected from the medical record. Lipid profile was measured in the morning after fasting 8-12 hours to measure total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglyceride. Demographic data collected were age, sex, diabetes, and hypertension. 

A total of 222 hemodialysis patients were enrolled in this study.  Median age in this study was 47.3 (22.6-75.6) years old.  The gender in this study was predominantly with male patient 146 patients (65.8%). Median duration of dialysis was 23.8 (6.1-116.9) months. Hypertension and diabetes were found in 130 patients (58.6%) and 139 patients (62.6%), respectively. A Multivariate Analysis of Variance (MANOVA) was performed to analyze the effect of dialysis duration and total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglyceride. Median of total cholesterol 169.3 (122.2-285.2), HDL 53.5 (9-78), LDL 98 (65-176), triglycerides 120 (86-268). There is no significant effect of dialysis duration on median total cholesterol, F(196, 25) = 1.367, p = 0.179. There is no significant effect of dialysis duration on median HDL cholesterol, F(196, 25) = 1.229, p = 0.278. There is no significant effect of dialysis duration on median LDL cholesterol, F(196, 25) = 1.199, p = 0.305. There is no significant effect of dialysis duration on median triglyceride (196, 25) = 1.093, p = 0.416.

In conclusion, there is no significant effect of dialysis duration on median total cholesterol, HDL, LDL, and triglyceride. A limitation of this study was not consider the use of lipid-lowering agents used.

Kewords