THE ASSOCIATION BETWEEN ESTIMATED GLOMERULAR FILTRATION RATE (EGFR) AT THE START OF DIALYSIS AND CLINICAL OUTCOMES IN A LATIN AMERICAN COHORT.

 

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https://storage.unitedwebnetwork.com/files/1099/2bd73886535f2dea77cd40d41f754021.pdf
THE ASSOCIATION BETWEEN ESTIMATED GLOMERULAR FILTRATION RATE (EGFR) AT THE START OF DIALYSIS AND CLINICAL OUTCOMES IN A LATIN AMERICAN COHORT.

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Peter
Rutherford
Peter Rutherford peter.rutherford@vantive.com Vantive corporation Medical Affairs Zurich Switzerland *
Mauricio Sanabria mauricio.sanabria@vantive.com Renal Care Services Latin America Medical Affairs Bogota Colombia -
Jasmin Vesga jasmin.vesga@vantive.com Renal Care Services Colombia Medical Affairs Bucaramanga Colombia -
Sergio Paez spaezm@unal.edu.co National University of Colombia Statistic Bogota Colombia -
Angela Rivera angela.rivera@vantive.com Vantive corporation Medical Affairs Deerfield United States -
 
 
 
 
 
 
 
 
 
 

The estimated glomerular filtration rate (eGFR) is used in clinical practice to help guide timing of dialysis initiation but does not guide the precise dialysis start. In addition, its association with dialysis initiation circumstances (planned vs unplanned start) and modality choice and early clinical outcomes remains unclear for Latin American populations. This study aimed to determine whether a lower eGFR at the start of dialysis is associated with unplanned initiation, modality use and poor clinical outcomes.

A retrospective cohort study was performed, including 2,829 patients with CKD stage G5 who were enrolled in the Renal Care Services (RCS) Nephroprotection Program in Colombia from 2016 to 2023. The patients were followed for one year, and the follow-up period was extended to 90 days for those who started dialysis. Of these patients, 1,471 patients initiating dialysis and were categorized into two groups according to their eGFR: ≤7 mL/min/1.73 m² and >7–15 mL/min/1.73 m². Associations between eGFR and clinical outcomes was evaluated using chi-square tests, with statistical significance was defined as p < 0.05.

1020 patients commenced dialysis with an eGFR of 7-15 ml/min and 451 with a eGFR of 0-7 ml/min. A significant association was found between eGFR and planned dialysis initiation (χ²(1) = 5.85, p = 0.016) with patients with eGFR more likely to start dialysis as planned initiation. The group with eGFR 7-15 ml/min had a higher probability of starting with PD on day 0 of dialysis ( χ² (1) =3.97, p=0.046).  Similarly, patients with an eGFR greater than 7 were more likely to have chosen a therapy and preferred peritoneal dialysis (PD) over hemodialysis (HD) (χ²(2)=9.26, p=0.001). However, no significant associations were observed for early mortality (p = 0.224) or dialysis access complications (p = 0.36) following dialysis initiation.


Table1. Demographic and clinical characteristics of the study population according to eGFR group.


Figure 1. A comparison of planned versus unplanned starts dialysis according to eGFR group.


A lower eGFR (<7ml/min) at the start of dialysis was associated with an unplanned start and a lower probabilty of starting with PD. These findings emphasize the importance of early referral to a nephrologist and then proactive planning as eGFR decline to optimize transition to dialysis.

Kewords