THE EFFECTIVENESS OF MORINGA OLEIFERA LEAF ON KIDNEY DAMAGE REPAIR ALBUMINURIA IN DIABETIC KIDNEY DISEASE

 

Certificate Output Instructions

For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".

To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".

 

 

Certificate Background

   

Presented the abstract " "
(Abstract co-author(s):  )

 

 

  Back
E-Poster Presentation

During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center. 

Preparing your E-Poster

Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.

​E-Poster Submission Deadline

Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.​

E-Poster Format Requirements
  • PDF file
  • Layout: Portrait (vertical orientation)
  • One page only (Dim A4: 210 x 297mm or PPT)
  • E-Poster can be prepared in PowerPoint (one (1) PowerPoint slide) but must be saved and submitted as PDF file.
  • File Size: Maximum file size is 2 Megabytes (2 MB)
  • No hyperlinks, animated images, animations, and slide transitions
  • Language: English
  • Include your abstract number
  • E-posters can include QR codes, tables and photos
https://storage.unitedwebnetwork.com/files/1099/e33c872f211701baa05ae164481a1cfc.pdf
THE EFFECTIVENESS OF MORINGA OLEIFERA LEAF ON KIDNEY DAMAGE REPAIR ALBUMINURIA IN DIABETIC KIDNEY DISEASE

Please follow the instructions below to input your abstract title.

Abstract titles should be brief and reflect the content of the abstract.

  • The title will not be accepted if it exceeds 25 words.
  • Type in CAPITAL LETTERS.
  • Lowercase may be used for abbreviations only, for example, mRNA.
Santy Ayu P
Perdhana
Santy Ayu P Perdhana santyayupp@gmail.com Dr. Moewardi Hospital Nephrology and Hypertension Surakarta Indonesia *
Ratih Tri Kusuma Dewi ratihsolo@gmail.com Dr. Moewardi Hospital Nephrology and Hypertension Surakarta Indonesia -
Bambang Purwanto bambangp.solo@yahoo.com Sebelas Maret University Nephrology and Hypertension Surakarta Indonesia -
Eti Poncorini etiponco@staff.uns.ac.id. Sebelas Maret University Public Health Surakarta Indonesia -
-
-
-
-
-
-
-
-
-
-
-

Diabetic Kidney Disease (DKD) is one of the causes of CKD which is characterized by albuminuria, a decrease in estimated Glomerular Filtration Rate (eGFR), or both. DKD increases cardiovascular disease mortality 20 - 30 times higher than general population. Moringa oleifera is a plant native to Ngawenombo Village  Kunduran District, Blora Regency, Central Java, Indonesia. Moringa oleifera leaf extract play an important role in the management of DKD. It contains crypto-chlorogenic acid, quercetin 3-O-glucoside and kaempferol 3-O-glucoside that have  antioxidant and antiinflammation effect to repair endothelial damage in glomerulus, decrease albuminuria levels. Hypotheses explain mechanism to slow down DKD progressivity, aiding control of glucose levels, reducing Renin-Angiotensin System (RAS) activation, and reducing fibrosis. It is necessary to conduct research of Moringa oleifera leaf extract to inhibit the progression of DKD, especially on albuminuria.

Randomised Control Trial (RCT) pre-test and post-test experimental studies  on  male Sprague dawley mice model of DKD. Total of 27 samples. Held in laboratory animal experiment in Yogyakarta from November 2024 – January 2025. Mice were made a DKD model by intraperitoneal injection of streptozotocin nicotinamide for 3 days then free treatment for 2 weeks. An albuminuria was carried out before therapy. The experimental animals were divided into 3 groups, DKD (Group 1), DKD + Moringa oleifera leaf extract 500mg/kg per oral for 28 days (Group 2), DKD + calcitriol 0,0045 mcg/200 gram per oral + Moringa oleifera leaf extract 500mg/kg for 28 days (Group 3). After that, albuminuria levels was checked again.

Groups 2 and 3 decreased albuminuria levels compared to group 1, and the one that lowered albuminuria the most was group 3. The combination group of calcitriol and Moringa oleifera  leaf extract best lowered levels of albuminuria (-4.18; p ≤ 0.001). 



Moringa oleifera  leaf extract lower albuminuria levels in  male Sprague dawley mice in a DKD model

Kewords