Impact on Water Consumption and Solute Clearance with a Reduction of Qd from 500 to 300 mL/min in Patients Undergoing Chronic Hemodialysis

 

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Impact on Water Consumption and Solute Clearance with a Reduction of Qd from 500 to 300 mL/min in Patients Undergoing Chronic Hemodialysis

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Enrique Iván
Rodríguez Garcia
Enrique Iván Rodríguez Garcia mcenriqueroga@hotmail.com Hospital General de Zona 197, IMSS Nephrology Texcoco Mexico *
Rosario Guadalupe Hernandez Ortega rosariohernandez0703@gmail.com Centro Médico ISSEMYM Ecatepec Nephrology Ecatepec Mexico -
Juan Sergio Barrón Morales mcenriqueroga@hotmail.com Centro Médico ISSEMYM Ecatepec Nephrology Ecatepec Mexico -
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Hemodialysis (HD) is one of the medical treatments with the greatest environmental impact. The delivered dialysis dose depends on the dialyzer KoA, blood flow rate (Qs), dialysate flow rate (Qd), ultrafiltration, and treatment time. Conventionally, a Qd of at least twice the Qs is recommended.

To reduce environmental impact and water consumption, strategies using lower Qd values (300 or 400 mL/min) have been proposed, though their results in solute clearance among patients have been variable.

Objective: To compare small and large molecular weight solute clearance and total water consumption using two different Qd strategies in a chronic HD center.

Prospective, single-center, non-randomized, crossover clinical trial. We included patients with chronic kidney disease (CKD) who had been on HD for more than three months, assigned to two groups:

Group A: HD three times per week using a Diacap Pro 19H α-polysulfone dialyzer for 3 hours, Qs 300 mL/min, Qd 500 mL/min (n=33).

Group B: HD three times per week using a Diacap Pro 19H α-polysulfone dialyzer for 3 hours, Qs 300 mL/min, Qd 300 mL/min (n=32).

Each patient received HD under both conditions (A and B) for one month. To assess small solute removal, we measured blood urea nitrogen (BUN), creatinine, and phosphorus; for large solutes, we measured beta-2 microglobulin.

Thirty-three patients were included, with a mean age of 49.5 years; 63% were men and 36% women. Vascular access distribution was as follows: 54% tunneled jugular catheter, 18% non-tunneled jugular catheter, and 21% arteriovenous fistula. An estimated total water saving of 14,292 liters was achieved over two months.


No significant differences were observed in solute clearance between both groups, while the lower Qd strategy significantly reduced water consumption. Therefore, a Qd of 300 mL/min should be considered a water-saving and equally effective alternative to Qd 500 mL/min.

Future directions: Multicenter, randomized studies with larger sample sizes are warranted to further evaluate outcomes such as survival, hospitalization rates, and quality of life.

Kewords