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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Preterm birth occurs during a critical period of nephrogenesis and may result in disrupted kidney development. Kidney size, adjusted for body surface area, is smaller in individuals born preterm, suggesting a lower nephron number. Population-based studies show increased risk of kidney disease and hypertension. Yet, the data on long-term consequences of preterm birth on renal function remain scarce. Studies assessing glomerular filtration rate (GFR) in individuals born preterm find values that are similar to, or slightly lower than, those of full-term peers. Normal GFR with presumably lower nephron number may suggest glomerular hyperfiltration. However, reports are limited by use of creatinine-based estimated GFR, which is imprecise for normal GFR values or small sample size.
The aims of the current study are to assess measured GFR (mGFR) and mGFR relative to total kidney volume in adults born very preterm in comparison to term controls.
This is a cross-sectional observational study of adults (18-40 years) born very preterm at <30 weeks gestational age (GA) between 1987-1997 vs. same age and race individuals born at term, in whom we measured GFR by 99mTc-DTPA plasma clearance and total kidney volume by MRI (ClinicalTrial.gov NCT04735315). Group comparisons were done using regression analyses.
78 adults born preterm (mean GA 27 weeks, mean birthweight 930 grams, mean age 30.0 years, 31 males) and 78 controls born at term (28.9 years, 32 males) were included. 24-hour ABPM systolic values were significantly higher in males (but not females) born preterm vs. term (120 ± 8 vs. 115 ± 7 mmHg); no differences were observed for the diastolic values. Serum creatinine and estimated GFR (CKD-EPI 2021 equation) were not different between groups. Total kidney volume was lower in both males and females preterm vs. term (median (IQR); males 156 (147, 165) vs. 170 (161, 179) and females 143 (136, 149) vs. 153 (146, 160) cm3/m2). mGFR was significantly lower in preterm vs. term (110 ± 22 vs. 117 ± 21 mL/min/1.73 m2; mean difference: -7 , 95% CI -14, -0.3). Biological sex-based analyses showed that mGFR was reduced by 16 mL/min/1.73 m2 (95% CI -27, -5) in males born preterm vs. term. However, in females, mGFR was comparable between groups. In the preterm group, 23% of males had at a least a mild reduction in mGFR (< 90 mL/min/1.73 m2). mGFR per unit of kidney volume was slightly higher in the preterm compared to the term group (0.44 ± 0.10 vs. 0.38 ± 0.08, mean difference: 0.05, 95% CI 0.02-0.08). When examining individuals based on sex, differences were statistically significant for females born preterm vs. term, but not in males (interaction prematurity status by sex: p<0.05).
This study shows that very preterm birth is associated with reduced mGFR in young adulthood, and that adults born preterm have increased eGFR per unit of kidney volume, demonstrating glomerular hyperfiltration.
