CARDIOVASCULAR RISK STRATIFICATION IN KIDNEY TRANSPLANT CANDIDATES: A SINGLE-CENTRE ANALYSIS FROM SRI LANKA

 

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CARDIOVASCULAR RISK STRATIFICATION IN KIDNEY TRANSPLANT CANDIDATES: A SINGLE-CENTRE ANALYSIS FROM SRI LANKA

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Dilukshi
Pilapitiya
Dilukshi Pilapitiya dilukshisam@gmail.com University Hospital General Sir John Kotelawala Defence University Department of Nephrology, Dialysis & Renal Transplant Colombo Sri Lanka *
Chula Herath chulaherath@gmail.com Sri Jayewardenepura General Hospital Nephrology, Dialysis & Renal Transplant Colombo Sri Lanka -
Chinthana Galahitiyawa chintanag@hotmail.com Sri Jayewardenepura General Hospital Nephrology, Dialysis & Renal Transplant Colombo Sri Lanka -
Rushdi Nizam rushdiem@gmail.com District General Hospital, Kalutara Nephrology, Dialysis & Renal Transplant Colombo Sri Lanka -
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Cardiovascular disease is a leading cause of morbidity in patients with chronic kidney disease, particularly around the time of kidney transplantation. In the absence of a universal protocol for pre-operative cardiac screening, clinical practice varies significantly. This study analyses the cardiac evaluation protocols and their outcomes for transplant recipients at our centre.

This retrospective analysis included 296 patients who underwent renal transplantation between 2004 and 2019 at Sri Jayewardenepura General Hospital. Data were collected from clinic records and bedhead tickets.

Among 296 patients, 21 had a reduced ejection fraction (EF<50%). Of these, 13 underwent coronary angiography (CAG), which identified coronary artery disease (CAD) in 11, with 6 requiring revascularization. 8 patients with no additional risk factors underwent no further evaluation.

 

Among 266 patients with EF >50%:

  115 had Diabetes Mellitus (DM):

§  27 with a history of IHD all underwent coronary angiogram (CAG): 14 had triple vessel disease (TVD), 4 had double vessel disease (DVD), 3 had single vessel disease (SVD), and 6 had minor plaque disease. Revascularization was required in 20 (10 CABG, 10 PCI).

§  88 without prior IHD:

§              30 aged >55 years: 29 underwent CAG (2 TVD, 2 DVD, 7 SVD, 15 minor plaque, 3 normal). Revascularization (PCI) was required in 7, CABG in 1. One patient underwent ETT with negative result.

§               58 aged <55 years: 38 underwent CAG, with 6 requiring revascularization.

 

o   151 were Non-Diabetic:

§  5 with a history of IHD all underwent screening; 1 ETT and CAG in other 4. One had TVD requiring CABG.

§  146 without prior IHD:

§              19 patients >55 years underwent screening (16 CAG, 3 ETT). CAG revealed 6 SVD, 1 DVD, 6 minor plaque, and 3 normal coronaries. Only 3 required revascularization.

§              127 patients < 55 years only 16% (n=21/127) were screened and only 3 needed revascularization (3 PCI for SVD).

Overall, 44% patients underwent coronary angiography. Of those who underwent CAG, 36% required an intervention. From the screened patients, most had minor plaque disease (48%) or normal coronaries (22%), and 64% did not require intervention. Although 78% of coronary angiographies showed positive findings, only 36% of patients required revascularization, with others managed medically.

This study emphasises the importance of standardised risk stratification in renal transplant candidates to minimise unnecessary invasive investigations while ensuring optimal detection of significant CAD. It highlights the high prevalence of occult CAD, particularly among diabetics, older age patients (>55 years), and those with a history of CAD, reinforcing the need for targeted preoperative cardiac screening in this high-risk cohort. Establishing cardiac risk stratification guidelines are particularly helpful for the resource poor setting where health economics can be directed to be used more cost effectively.

Kewords