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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
The systemic metabolic role of the kidneys remains underexplored, particularly in the context of renal resilience, the functional reserve capacity that becomes apparent after living kidney donation. Therefore, the aim of this study was to investigate metabolic changes after single kidney donation and uncover if the observed systemic metabolic effects differ in high versus low renal resilience.
From the TransplantLines Biobank and Cohort study, Groningen, the Netherlands, kidney donors were propensity score matched based on high (n=19) and low resilience (n=19). Renal resilience was defined as: (pre-donation measured glomerular filtration rate (mGFR) / 2) - post-donation mGFR. Untargeted metabolomics (quadrupole time-of-flight mass spectrometry) was performed on plasma samples collected prior and 3 months post-donation. Differences between pre- and post-donation were tested using within-subject ANCOVA, implemented as a linear regression model which included a fixed effect for each participant.
Pre-donation, the median (interquartile range, IQR) donor age was 56.0 (50.3-60.0) and 19 (50%) were females. The median measured glomerular filtration rate of the donors was 103.9 (91.0 – 119.3) mL/min pre-donation, which decreased to 69.3 (60.2 – 80.4) mL/min post-donation. The median renal resilience was 8.6 (4.9 – 10.0) mL/min in the low group and 25.1 (23.0 – 30.8) mL/min in the high group. In total, 61 metabolites changed significantly post donation, 41 increased and 20 decreased (Figure 1). These metabolites are involved in metabolic pathways such as renin secretion, vitamin B6 metabolism, folate biosynthesis, histidine metabolism, taste transduction and drug metabolism.
Kidney donation results in significant changes in the global plasma metabolome, highlighting the systemic metabolic role of the kidneys and guiding potential therapeutic strategies to maintain kidney health post donation and in renal disease.
