AMINO ACID AND DIPEPTIDE COMPLEX AB070597 HELPS RETAIN NORMAL RENAL FUNCTION IN HEALTHY VOLUNTEERS: A CLINICAL TRIAL

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AMINO ACID AND DIPEPTIDE COMPLEX AB070597 HELPS RETAIN NORMAL RENAL FUNCTION IN HEALTHY VOLUNTEERS: A CLINICAL TRIAL

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Co-author 1

Junichi Yatabe jyatabe@telemedease.org Fukushima Medical University Department of Digital Health Services Research Fukushima Japan *

Co-author 2

Midori Yatabe midorisy@telemedease.org Fukushima Medical University Department of Digital Health Services Research Fukushima Japan -

Co-author 3

Takamasa Matsuda masudat@hc-sys.jp Healthcare Systems Co., Ltd. Clinical Research Department Tokyo Japan -

Co-author 4

Chihiro Nagayama jyatabe@telemedease.org Healthcare Systems Co., Ltd. Clinical Research Department Tokyo Japan -

Co-author 5

Kana Sogai jyatabe@telemedease.org Zpeer Inc. N/A Tokyo Japan -

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Introduction

Progressive kidney damage and function loss are hallmarks of chronic kidney disease (CKD). CKD has no known cure; however, therapies can alleviate symptoms and prevent further progression. Uremia-related changes in the plasma levels of many amino acids occur in CKD. Consequently, the addition of specific amino acids to diets may improve kidney function. AB070597 is a patented dietary supplement containing amino acids and a peptide. We examined the efficacy of AB070597 in improving kidney function in participants recruited from the general public who were screened using their estimated glomerular filtration rates (eGFRs).

Methods

The trial included 40 Japanese individuals aged 20–64 years with low eGFR calculated from serum creatinine (eGFRcrea) levels. They were categorized into two groups, placebo and AB070597, wherein they consumed test foods A and B, respectively. The treatment lasted 12 weeks. Biochemical parameters and urinalysis results were obtained at screening and after 12 weeks. Thirty-seven subjects were included in the analyses.

Results

eGFRcrea and eGFR calculated from serum cystatin C (eGFRcys) levels showed no significant within- or between-group differences. Subgroup analysis of participants with eGFRcrea ≥ 60 mL/min/1.73 m2 revealed that eGFRcrea did not differ significantly within or between groups, but eGFRcys was significantly lower in the placebo group at week 12 than at week 0. The change from week 0 to 12 was significantly lower in the placebo group than in the AB070597 group.

Conclusion

These findings suggest that routine consumption of AB070597 may help maintain renal function in healthy individuals.

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