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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Snake envenoming poses a significant health risk globally, particularly in low-to middle-income countries. Bothrops snakes, a major cause of snakebites in Latin America, trigger a complex hemostatic and inflammatory response. This study aims to measure the serum levels of interleukin-33 (IL-33), Von Willebrand factor A2 (vWF-A2), and vascular biomarkers in patients and to evaluate the effect of antivenom.
This is an observational, prospective study, with hospitalized patients bitten by Bothrops sp. in Fortaleza, Northeast Brazil. Patient demographics and clinical data were collected, and blood samples were analyzed at three intervals: upon admission, and 12-16 and 24-28 hours post-antivenom administration. Biomarkers, including Angiopoietin-1, Angiopoietin-2, Syndecan-1, vascular cell adhesion molecule 1 (VCAM-1), interleukin 33 (IL-33), and Von Willebrand factor A2 (vWF-A2), were measured using ELISA, and coagulation parameters were assessed.
The study included 31 patients, of whom 14 presented with bleeding symptoms at admission. No significant differences were found in post-bite hours on hospital admission, related to traditional laboratory parameters, gender, and age between the bleeding and non-bleeding groups at baseline. The bleeding group presented higher IL-33 levels during hospital admission (p < 0.05) and a significant decrease in hemoglobin and hematocrit levels (p < 0.05) after 24 h of antivenom administration. Non-traditional biomarker analysis during hospital admission revealed that the level of IL-33 correlated positively with Von Willebrand Factor (vWF) (Rho Spearman 0.59, p = 0.000299), estimated Glomerular Filtration Rate (eGFR) (Rho Spearman 0.538, p = 0.047), and negatively with Angiopoietin-1 (Angio-1) (Rho Spearman -0.515, p = 0.0225).
High serum IL-33 levels on hospital admission due to Bothrops snakebite envenoming are a potential biomarker to predict hemorrhagic and kidney clinical complications. The therapeutic effect of antivenom therapy was demonstrated by the early decrease in IL-33 and vWF in both patient groups. The study supports the importance of this life-saving therapy in managing snakebite patients.
